Therapies for polycystic kidney disease

被引:1
作者
Bissler, John J. [1 ]
机构
[1] Univ Tennessee, Hlth Sci Ctr, Childrens Fdn Res Ctr, Div Nephrol,Dept Pediat,St Jude Childrens Res Hos, Memphis, TN 38103 USA
关键词
chronic kidney disease; polycystic kidney disease; primary cilia; renal cyst; TUBEROUS SCLEROSIS COMPLEX; ANGIOMYOLIPOMA; PROGRESSION; EVEROLIMUS; SIROLIMUS; GROWTH;
D O I
10.1097/MOP.0000000000000202
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Purpose of review All polycystic diseases of the kidney exhibit tubular or saccular cysts. The cysts can either be open to the tubule or isolated sacs that have lost their connections. Polycystic kidney diseases derived from different genetic mutations share basic mechanisms of cytogenesis, formation, and progressive enlargement, involving a cellular organelle called the primary cilium. Given the mechanistic commonalities, this review will focus on the therapeutic approaches currently available or under development that likely apply to all inherited renal cystic diseases. Recent findings Recent advances in clinical trials and preclinical experiments have illuminated common signaling pathway involvement. Summary Avoidance of nephrotoxic drugs or radio-contrast and maintaining normal BMI are routine preventive measures. Limiting the intake of calories, salt, and protein, together with increased intake of fruits, vegetables, and water are dietary treatments that should be started early in the course of the disease. Potential pharmacological treatments targeting cyst initiation and progression are on the horizon.
引用
收藏
页码:227 / 232
页数:6
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