Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents

被引：248
作者：
Nickoloff, BJ
Osborne, BA
Miele, L
机构：
[1] Univ Illinois, Dept Biopharmaceut Sci, Chicago, IL 60612 USA
[2] Loyola Univ, Dept Pathol, Chicago, IL 60611 USA
[3] Loyola Univ, Cardinal Bernardin Canc Ctr, Chicago, IL 60611 USA
[4] Univ Massachusetts, Dept Vet & Anim Sci, Amherst, MA 01003 USA
[5] Univ Illinois, Ctr Canc, Chicago, IL 60612 USA
来源：
ONCOGENE | 2003年 / 22卷 / 42期
关键词：
Notch; cancer; leukemia; therapeutic targets; signalling;
D O I：
10.1038/sj.onc.1206758
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Notch signaling controls cell fate decisions including during development and stem cell renewal and differentiation in many postnatal tissues. Increasing evidence suggests that the Notch signaling network is frequently deregulated in human malignancies and that genetic or pharmacological manipulation of Notch signaling is a novel potential strategy for the treatment of human neoplasms. This review article summarizes the most recent preclinical and clinical evidence linking Notch signaling to cancer, delineates questions that remain unanswered and explores potential biopharmacological strategies to manipulate Notch signaling in vivo.
引用
收藏
页码：6598 / 6608
页数：11
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