Elevated HLA-E levels in human glioblastomas but not in grade I to III astrocytomas correlate with infiltrating CD8+ cells

被引：47
作者：
Mittelbronn, Michel
Simon, Perikles
Loeffler, Christian
Capper, David
Bunz, Benedikt
Harter, Patrick
Schlaszus, Holger
Schleich, Ariane
Tabatabai, Ghazaleh
Goeppert, Benjamin
Meyermann, Richard
Weller, Michael
Wischhusen, Joerg
机构：
[1] Univ Tubingen, Inst Brain Res, D-72076 Tubingen, Germany
[2] Univ Tubingen, Dept Sports Med, D-72074 Tubingen, Germany
[3] Univ Tubingen, Hertie Clin Inst Brain Res, Dept Gen Neurol, D-72074 Tubingen, Germany
[4] Univ Zurich Hosp, Inst Neuropathol, CH-8091 Zurich, Switzerland
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2007年 / 189卷 / 1-2期
关键词：
HLA-E; CD8; cytotoxic T cells; NK cells; human astrocytomas; immune escape;
D O I：
10.1016/j.jneuroim.2007.07.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
HLA-E is a ligand for the immune-inhibitory NKG2A receptor expressed on NK and T cells. To investigate HLA-E expression and immune cell infiltration in human astrocytic tumors in vivo, we analyzed normal CNS controls and astrocytomas of all WHO grades by immunohistochemistry. Both, CD8+ immune cell infiltration and HLA-E expression were significantly higher in astrocytic tumors than in normal brain. Further, HLA-E expression levels and immune cell infiltration were significantly correlated in WHO grade IV glioblastomas. Thus, HLA-E overexpression in glioblastomas may be triggered by T and NK cell infiltration. (C) 2007 Elsevier B.V. All rights reserved.
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收藏
页码：50 / 58
页数：9
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