Anti-inflammatory neuropeptide receptors: new therapeutic targets for immune disorders?

被引：43
作者：
Gonzalez-Rey, Elena
Delgado, Mario [1 ]
机构：
[1] CSIC, Inst Parasitol & Biomed, Granada 18100, Spain
[2] Univ Seville, Dept Bioquim Med & Biol Mol, Seville 41009, Spain
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2007年 / 28卷 / 09期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/j.tips.2007.07.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The loss of immune tolerance results in the breakdown of immune homeostasis and the appearance of exacerbated inflammatory conditions. Some anti-inflammatory neuropeptides have recently emerged as endogenous factors participating in the maintenance of immune tolerance. The effects of these neuropeptides in self-tolerance primarily depend on the activation of cAMP-protein kinase A signaling and the regulation of various transduction pathways involved in the expression of many immune factors. Understanding of the structure-function relationship of anti-inflammatory neuropeptides and their receptors will facilitate the development of novel pharmacological agents for the treatment of immune disorders.
引用
收藏
页码：482 / 491
页数：10
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