Broad and strong: the ultimate antibody to dengue virus

被引:17
作者
Coloma, Josefina [1 ]
Harris, Eva [1 ]
机构
[1] Univ Calif Berkeley, Sch Publ Hlth, Div Infect Dis & Vaccinol, Berkeley, CA 94720 USA
关键词
NEUTRALIZING ANTIBODIES; INFECTION; EPITOPES; BIND;
D O I
10.1038/ni.3081
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The identification of a new class of cross-reactive monoclonal antibodies that strongly neutralize all four serotypes of dengue virus has important implications for vaccine design as well as for the evaluation of vaccines and of natural infection with dengue virus.
引用
收藏
页码:135 / 137
页数:4
相关论文
共 15 条
[1]   The Human Immune Response to Dengue Virus Is Dominated by Highly Cross-Reactive Antibodies Endowed with Neutralizing and Enhancing Activity [J].
Beltramello, Martina ;
Williams, Katherine L. ;
Simmons, Cameron P. ;
Macagno, Annalisa ;
Simonelli, Luca ;
Quyen, Nguyen Than Ha ;
Sukupolvi-Petty, Soila ;
Navarro-Sanchez, Erika ;
Young, Paul R. ;
de Silva, Aravinda M. ;
Rey, Felix A. ;
Varani, Luca ;
Whitehead, Stephen S. ;
Diamond, Michael S. ;
Harris, Eva ;
Lanzavecchia, Antonio ;
Sallusto, Federica .
CELL HOST & MICROBE, 2010, 8 (03) :271-283
[2]   Structural basis for the preferential recognition of immature flaviviruses by a fusion-loop antibody [J].
Cherrier, Mickael V. ;
Kaufmann, Baerbel ;
Nybakken, Grant E. ;
Lok, Shee-Mei ;
Warren, Julia T. ;
Chen, Beverly R. ;
Nelson, Christopher A. ;
Kostyuchenko, Victor A. ;
Holdaway, Heather A. ;
Chipman, Paul R. ;
Kuhn, Richard J. ;
Diamond, Michael S. ;
Rossmann, Michael G. ;
Fremont, Daved H. .
EMBO JOURNAL, 2009, 28 (20) :3269-3276
[3]   Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions [J].
de Alwis, Ruklanthi ;
Smith, Scott A. ;
Olivarez, Nicholas P. ;
Messer, William B. ;
Huynh, Jeremy P. ;
Wahala, Wahala M. P. B. ;
White, Laura J. ;
Diamond, Michael S. ;
Baric, Ralph S. ;
Crowe, James E., Jr. ;
de Silva, Aravinda M. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (19) :7439-7444
[4]   In-Depth Analysis of the Antibody Response of Individuals Exposed to Primary Dengue Virus Infection [J].
de Alwis, Ruklanthi ;
Beltramello, Martina ;
Messer, William B. ;
Sukupolvi-Petty, Soila ;
Wahala, Wahala M. P. B. ;
Kraus, Annette ;
Olivarez, Nicholas P. ;
Quang Pham ;
Brian, James ;
Tsai, Wen-Yang ;
Wang, Wei-Kung ;
Halstead, Scott ;
Kliks, Srisakul ;
Diamond, Michael S. ;
Baric, Ralph ;
Lanzavecchia, Antonio ;
Sallusto, Federica ;
de Silva, Aravinda M. .
PLOS NEGLECTED TROPICAL DISEASES, 2011, 5 (06)
[5]   A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus [J].
Dejnirattisai, Wanwisa ;
Wongwiwat, Wiyada ;
Supasa, Sunpetchuda ;
Zhang, Xiaokang ;
Dai, Xinghong ;
Rouvinsky, Alexander ;
Jumnainsong, Amonrat ;
Edwards, Carolyn ;
Nguyen Than Ha Quyen ;
Duangchinda, Thaneeya ;
Grimes, Jonathan M. ;
Tsai, Wen-Yang ;
Lai, Chih-Yun ;
Wang, Wei-Kung ;
Malasit, Prida ;
Farrar, Jeremy ;
Simmons, Cameron P. ;
Zhou, Z. Hong ;
Rey, Felix A. ;
Mongkolsapaya, Juthathip ;
Screaton, Gavin R. .
NATURE IMMUNOLOGY, 2015, 16 (02) :170-+
[6]   Cross-Reacting Antibodies Enhance Dengue Virus Infection in Humans [J].
Dejnirattisai, Wanwisa ;
Jumnainsong, Amonrat ;
Onsirisakul, Naruthai ;
Fitton, Patricia ;
Vasanawathana, Sirijitt ;
Limpitikul, Wannee ;
Puttikhunt, Chunya ;
Edwards, Carolyn ;
Duangchinda, Thaneeya ;
Supasa, Sunpetchuda ;
Chawansuntati, Kriangkrai ;
Malasit, Prida ;
Mongkolsapaya, Juthathip ;
Screaton, Gavin .
SCIENCE, 2010, 328 (5979) :745-748
[7]   A potent anti-dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface [J].
Fibriansah, Guntur ;
Tan, Joanne L. ;
Smith, Scott A. ;
de Alwis, Adamberage R. ;
Thiam-Seng Ng ;
Kostyuchenko, Victor A. ;
Ibarra, Kristie D. ;
Wang, Jiaqi ;
Harris, Eva ;
de Silva, Aravinda ;
Crowe, James E., Jr. ;
Lok, Shee-Mei .
EMBO MOLECULAR MEDICINE, 2014, 6 (03) :358-371
[8]   Degrees of maturity: the complex structure and biology of flaviviruses [J].
Pierson, Theodore C. ;
Diamond, Michael S. .
CURRENT OPINION IN VIROLOGY, 2012, 2 (02) :168-175
[9]   The Potent and Broadly Neutralizing Human Dengue Virus-Specific Monoclonal Antibody 1C19 Reveals a Unique Cross-Reactive Epitope on the bc Loop of Domain II of the Envelope Protein [J].
Smith, Scott A. ;
de Alwis, A. Ruklanthi ;
Kose, Nurgun ;
Harris, Eva ;
Ibarra, Kristie D. ;
Kahle, Kristen M. ;
Pfaff, Jennifer M. ;
Xiang, Xiaoxiao ;
Doranz, Benjamin J. ;
de Silva, Aravinda M. ;
Austin, S. Kyle ;
Sukupolvi-Petty, Soila ;
Diamond, Michael S. ;
Crowe, James E., Jr. .
MBIO, 2013, 4 (06)
[10]   Persistence of Circulating Memory B Cell Clones with Potential for Dengue Virus Disease Enhancement for Decades following Infection [J].
Smith, Scott A. ;
Zhou, Yang ;
Olivarez, Nicholas P. ;
Broadwater, Anne H. ;
de Silva, Aravinda M. ;
Crowe, James E., Jr. .
JOURNAL OF VIROLOGY, 2012, 86 (05) :2665-2675