Synthesis, characterizations, and biocompatibility evaluation of polycaprolactone-MXene electrospun fibers

被引:86
作者
Awasthi, Ganesh Prasad [1 ]
Maharjan, Bikendra [1 ]
Shrestha, Sita [1 ]
Bhattarai, Deval Prasad [1 ,2 ]
Yoon, Deockhee [1 ]
Park, Chan Hee [1 ,3 ]
Kim, Cheol Sang [1 ,3 ]
机构
[1] Jeonbuk Natl Univ, Grad Sch, Dept Bionanosyst Engn, Jeonju 561756, South Korea
[2] Tribhuvan Univ, Dept Chem, Amrit Campus, Kathmandu, Nepal
[3] Jeonbuk Natl Univ, Div Mech Design Engn, Jeonju 561756, South Korea
基金
新加坡国家研究基金会;
关键词
Polycaprolactone; MXene; Electrospinning; Fibroblasts; Pre-osteoblasts; Biocompatibility; 2-DIMENSIONAL TITANIUM CARBIDE; MULTIWALL CARBON NANOTUBES; EPSILON-CAPROLACTONE; MECHANICAL STRENGTH; IN-VITRO; COMPOSITE; NANOFIBERS; EFFICIENT; SCAFFOLD; NANOCOMPOSITE;
D O I
10.1016/j.colsurfa.2019.124282
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
The two-dimensional (2D) MXene has attracted great interest in the field of biomedical applications. Here, we synthesized for the first time, polycaprolactone-MXene (PCL-MXene) composite electrospun fibers and evaluated its possible applications in biomedical areas. The composite fibers were characterized by field emission scanning electron microscopy, transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, thermogravimetric analysis/differential scanning calorimetry, mechanical strength, and contact angle. Additionally, biocompatibility evaluation of the as-synthesized composite fibers was carried out on fibroblasts (NIH-3T3) and preosteoblasts (MC3T3-E1) cell lines, as a model. Besides these, possible biomineralization activity of the composites fibers was also determined for the harden tissues formation. The results showed that PCL-MXene composite electrospun fibers were cell friendly for both cell lines. However, pre-osteoblast cells exhibited higher cell viability compared to fibroblasts. Considering auspicious results, this work is expected to open the possible pathway for the expanded applications of MXene based composites in biomedical applications.
引用
收藏
页数:10
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