Synthesis of novel heterocyclic fused pyrimidin-4-one derivatives from imino-1,2,3-dithiazoles

被引：1

作者：

Pereira, Maria de Fatima ^{[1
,2
]}

Sarghe, Elena ^{[2
]}

Rouillard, Herve ^{[2
]}

Domon, Lisianne ^{[2
]}

Cherouvrier, Jean-Rene ^{[2
]}

Thiery, Valerie ^{[2
]}

机构：

[1] Normandie Univ, UNICAEN, CERMN, F-14032 Caen, France

[2] Univ La Rochelle, UMR CNRS 7266, LIttoral Environm Soc, LIENSs,Fac Sci & Technol, Ave Michel Crepeau, F-17042 La Rochelle, France

来源：

ARKIVOC | 2017年

关键词：

Imino-1,2,3-dithiazoles; Appel's salt; thieno[2,3-d]pyrimidin-4-ones; heterocyclic fused pyrimidin-4-ones; EFFICIENT SYNTHESIS; KINASE INHIBITORS; DISCOVERY; THIENOPYRIMIDINONES; SCAFFOLD; SAR;

D O I：

10.24820/ark.5550190.p010.256

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Extending the potential applications of 4,5-dichloro-1,2,3-dithiazolium chloride chemistry, we investigated the synthesis of original derivatives of thieno[2,3-d]pyrimidin-4-one system by condensation of alkyl and aromatic diamines with 2-N-iminodithiazolothiophene derivatives. We continued our study for access to novel pyrazolo-and pyrido-fused pyrimidinones using the potential applications of Appel's salt chemistry.

引用

页码：335 / 345

页数：11

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