Role of GPR40 in pathogenesis and treatment of Alzheimer's disease and type 2 diabetic dementia

被引：39
作者：
Chen, Jing-Jing [1 ]
Gong, Yu-Hang [1 ]
He, Ling [1 ]
机构：
[1] China Pharmaceut Univ, Dept Pharmacol, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China
来源：
JOURNAL OF DRUG TARGETING | 2019年 / 27卷 / 04期
基金：
中国国家自然科学基金;
关键词：
G-protein coupled receptor 40; Alzheimer's disease; type 2 diabetic dementia; phospholipase C; protein kinase B; ACID RECEPTOR GPR40; BRAIN INSULIN-RESISTANCE; PANCREATIC BETA-CELLS; GLP-1; SECRETION; ORAL TREATMENT; AMYLOID-BETA; DISCOVERY; AGONISTS; POTENT; ACTIVATION;
D O I：
10.1080/1061186X.2018.1491979
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
G-protein coupled receptor 40 (GPR40) is also known as free fatty acid receptor 1. It is a typical 7 transmembrane receptor and currently the natural receptor of the saturated or unsaturated long-chain fatty acids. It could trigger the intracellular signalling pathway when combined with the free long-chain fatty acids, thereby controlling cells physiological function. In this review, we summarised the relationships and the potential mechanisms between the promising target GPR40, and pathogenesis and treatment of Alzheimer's disease and type 2 diabetic dementia. It may provide a theoretical reference for the development of clinical drug targeting GPR40.
引用
收藏
页码：347 / 354
页数：8
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