Role of GPR40 in pathogenesis and treatment of Alzheimer's disease and type 2 diabetic dementia

被引：39

作者：

Chen, Jing-Jing ^{[1
]}

Gong, Yu-Hang ^{[1
]}

He, Ling ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Pharmacol, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China

来源：

JOURNAL OF DRUG TARGETING | 2019年 / 27卷 / 04期

基金：

中国国家自然科学基金;

关键词：

G-protein coupled receptor 40; Alzheimer's disease; type 2 diabetic dementia; phospholipase C; protein kinase B; ACID RECEPTOR GPR40; BRAIN INSULIN-RESISTANCE; PANCREATIC BETA-CELLS; GLP-1; SECRETION; ORAL TREATMENT; AMYLOID-BETA; DISCOVERY; AGONISTS; POTENT; ACTIVATION;

D O I：

10.1080/1061186X.2018.1491979

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

G-protein coupled receptor 40 (GPR40) is also known as free fatty acid receptor 1. It is a typical 7 transmembrane receptor and currently the natural receptor of the saturated or unsaturated long-chain fatty acids. It could trigger the intracellular signalling pathway when combined with the free long-chain fatty acids, thereby controlling cells physiological function. In this review, we summarised the relationships and the potential mechanisms between the promising target GPR40, and pathogenesis and treatment of Alzheimer's disease and type 2 diabetic dementia. It may provide a theoretical reference for the development of clinical drug targeting GPR40.

引用

页码：347 / 354

页数：8

共 71 条

[1]

[Anonymous], 2013, IDF DIABETES ATLAS

[2] Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): an emerging target for type 2 diabetes [J].

Bharate, Sandip B. ;

Nemmani, Kumar V. S. ;

Vishwakarma, Ram A. .

EXPERT OPINION ON THERAPEUTIC PATENTS, 2009, 19 (02) :237-264

[3] The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids [J].

Briscoe, CP ;

Tadayyon, M ;

Andrews, JL ;

Benson, WG ;

Chambers, JK ;

Eilert, MM ;

Ellis, C ;

Elshourbagy, NA ;

Goetz, AS ;

Minnick, DT ;

Murdock, PR ;

Sauls, HR ;

Shabon, U ;

Spinage, LD ;

Strum, JC ;

Szekeres, PG ;

Tan, KB ;

Way, JM ;

Ignar, DM ;

Wilson, S ;

Muir, AI .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (13) :11303-11311

[4] Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist [J].

Brown, Sean P. ;

Dransfield, Paul J. ;

Vimolratana, Marc ;

Jiao, XianYun ;

Zhu, Liusheng ;

Pattaropong, Vatee ;

Sun, Ying ;

Liu, Jinqian ;

Luo, Jian ;

Zhang, Jane ;

Wong, Simon ;

Zhuang, Run ;

Guo, Qi ;

Li, Frank ;

Medina, Julio C. ;

Swaminath, Gayathri ;

Lin, Daniel C. -H. ;

Houze, Jonathan B. .

ACS MEDICINAL CHEMISTRY LETTERS, 2012, 3 (09) :726-730

[5] Blood-derived amyloid-β protein induces Alzheimer's disease pathologies [J].

Bu, X-L ;

Xiang, Y. ;

Jin, W-S ;

Wang, J. ;

Shen, L-L ;

Huang, Z-L ;

Zhang, K. ;

Liu, Y-H ;

Zeng, F. ;

Liu, J-H ;

Sun, H-L ;

Zhuang, Z-Q ;

Chen, S-H ;

Yao, X-Q ;

Giunta, B. ;

Shan, Y-C ;

Tan, J. ;

Chen, X-W ;

Dong, Z-F ;

Zhou, H-D ;

Zhou, X-F ;

Song, W. ;

Wang, Y-J .

MOLECULAR PSYCHIATRY, 2018, 23 (09) :1948-1956

[6] TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial [J].

Burant, Charles F. ;

Viswanathan, Prabhakar ;

Marcinak, John ;

Cao, Charlie ;

Vakilynejad, Majid ;

Xie, Benhuai ;

Leifke, Eckhard .

LANCET, 2012, 379 (9824) :1403-1411

[7] Resveratrol mitigates lipopolysaccharide- and Aß-mediated microglial inflammation by inhibiting the TLR4/NF-?B/STAT signaling cascade [J].

Capiralla, Hemachander ;

Vingtdeux, Valerie ;

Zhao, Haitian ;

Sankowski, Roman ;

Al-Abed, Yousef ;

Davies, Peter ;

Marambaud, Philippe .

JOURNAL OF NEUROCHEMISTRY, 2012, 120 (03) :461-472

[8] Discovery of a Potent and Selective Free Fatty Acid Receptor 1 Agonist with Low Lipophilicity and High Oral Bioavailability [J].

Christiansen, Elisabeth ;

Due-Hansen, Maria E. ;

Urban, Christian ;

Grundmann, Manuel ;

Schmidt, Johannes ;

Hansen, Steffen V. F. ;

Hudson, Brian D. ;

Zaibi, Mohamed ;

Markussen, Stine B. ;

Hagesaether, Ellen ;

Milligan, Graeme ;

Cawthorne, Michael A. ;

Kostenis, Evi ;

Kassack, Matthias U. ;

Ulven, Trond .

JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (03) :982-992

[9] Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonists: Mesylpropoxy Appendage Lowers Lipophilicity and Improves ADME Properties [J].

Christiansen, Elisabeth ;

Due-Hansen, Maria E. ;

Urban, Christian ;

Grundmann, Manuel ;

Schroeder, Ralf ;

Hudson, Brian D. ;

Milligan, Graeme ;

Cawthorne, Michael A. ;

Kostenis, Evi ;

Kassack, Matthias U. ;

Ulven, Trond .

JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (14) :6624-6628

[10] Insulin and Alzheimer's Disease: Untangling the Web [J].

Craft, Suzanne ;

Cholerton, Brenna ;

Baker, Laura D. .

JOURNAL OF ALZHEIMERS DISEASE, 2013, 33 :S263-S275

← 1 2 3 4 5 6 7 8 →