Synthesis of the novel trimeric benzamides-potential inhibitors of protein-protein interactions

被引：12
|
作者：
Kulikov, Oleg V. [1 ]
Hamilton, Andrew D. [1 ,2 ]
机构：
[1] Yale Univ, Dept Chem, New Haven, CT 06511 USA
[2] Univ Oxford, Dept Chem, Oxford OX1 3TA, England
来源：
RSC ADVANCES | 2012年 / 2卷 / 06期
基金：
美国国家科学基金会;
关键词：
ALPHA-HELIX MIMETICS; AMIDE FOLDAMERS; MOLECULES; DESIGN; FAMILY;
D O I：
10.1039/c2ra01153k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The synthesis of the family of new non-natural trimeric oligobenzamides (potential inhibitors of protein-protein interactions) bearing the following groups (R = isobutyl, isopropyl, CH2CONH2, (CH2)(4)NH2, benzyl) that mimic different amino acid residues (leucine, valine, asparagine, lysine, phenylalanine) was accomplished through an iterative (n + 1) elongation approach that includes reduction of the NO2-group (Pd/C, H-2) and subsequent amide coupling in the presence of Mukaiyama's reagent.
引用
收藏
页码：2454 / 2461
页数：8
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