A decade of surprises for tRNA nuclear-cytoplasmic dynamics

被引：58

作者：

Hopper, Anita K. ^{[1
]}

Shaheen, Hussam H. ^{[1
,2
]}

机构：

[1] Ohio State Univ, Dept Mol Genet, Columbus, OH 43210 USA

[2] Avon Prod, Suffern, NY 10901 USA

来源：

TRENDS IN CELL BIOLOGY | 2008年 / 18卷 / 03期

关键词：

D O I：

10.1016/j.tcb.2008.01.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The biosynthesis of tRNA was previously thought to occur solely in the nucleus, with tRNA functioning only in the cytoplasm of eukaryotic cells. However, recent publications have reported that pre-tRNA splicing can occur in the cytoplasm, that aminoacylation can occur in the nucleus and that tRNA can travel in a retrograde direction from the cytoplasm to the nucleus. Moreover, the subcellular distribution of tRNA seems to serve unanticipated functions in diverse processes, including response to nutrient availability, DNA repair and HIV replication.

引用

页码：98 / 104

页数：7

共 62 条

[11] Nuclear translation: What is the evidence? [J].

Dahlberg, JE ;

Lund, E ;

Goodwin, EB .

RNA, 2003, 9 (01) :1-8

[12] RNA quality control in eukaryotes [J].

Doma, Meenakshi K. ;

Parker, Roy .

CELL, 2007, 131 (04) :660-668

[13] Plant pre-tRNA splicing enzymes are targeted to multiple cellular compartments [J].

Englert, Markus ;

Latz, Andreas ;

Becker, Dirk ;

Gimple, Olaf ;

Beier, Hildburg ;

Akama, Kazuhito .

BIOCHIMIE, 2007, 89 (11) :1351-1365

[14] A Los1p-independent pathway for nuclear export of intronless tRNAs in Saccharomyces cerevisiae [J].

Feng, WQ ;

Hopper, AK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (08) :5412-5417

[15] The tRNA aminoacylation co-factor Arc1p is excluded from the nucleus by an Xpo1p-dependent mechanism [J].

Galani, K ;

Hurt, E ;

Simos, G .

FEBS LETTERS, 2005, 579 (05) :969-975

[16] Impaired tRNA nuclear export links DNA damage and cell-cycle checkpoint [J].

Ghavidel, Ata ;

Kislinger, Thomas ;

Pogoutse, Oxana ;

Sopko, Richelle ;

Jurisica, Igor ;

Emili, Andrew .

CELL, 2007, 131 (05) :915-926

[17] Arc1p is required for cytoplasmic confinement of synthetases and tRNA [J].

Golinelli-Cohen, Marie-Pierre ;

Mirande, Marc .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2007, 300 (1-2) :47-59

[18] Transport between the cell nucleus and the cytoplasm [J].

Görlich, D ;

Kutay, U .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1999, 15 :607-660

[19]

Grosshans H, 2000, GENE DEV, V14, P830

[20] Depletion of Saccharomyces cerevisiae tRNAHis guanylyltransferase Thg1p leads to uncharged tRNAHis with additional m5C [J].

Gu, WF ;

Hurto, RL ;

Hopper, AK ;

Grayhack, EJ ;

Phizicky, EM .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (18) :8191-8201

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