Early-life exposome and lung function in children in Europe: an analysis of data from the longitudinal, population-based HELIX cohort

被引：114

作者：

Agier, Lydiane ^{[1
]}

Basagana, Xavier ^{[2
,3
,4
]}

Maitre, Lea ^{[2
,3
,4
]}

Granum, Berit ^{[5
]}

Bird, Philippa K. ^{[6
]}

Casas, Maribel ^{[2
,3
,4
]}

Oftedal, Bente ^{[5
]}

Wright, John ^{[6
]}

Andrusaityte, Sandra ^{[7
]}

de Castro, Montserrat ^{[2
,3
,4
]}

Cequier, Enrique ^{[5
]}

Chatzi, Leda ^{[8
,9
,10
]}

Donaire-Gonzalez, David ^{[2
,3
,4
]}

Grazuleviciene, Regina ^{[7
]}

Haug, Line S. ^{[5
]}

Sakhi, Amrit K. ^{[5
]}

Leventakou, Vasiliki ^{[10
]}

McEachan, Rosemary ^{[6
]}

Nieuwenhuijsen, Mark ^{[2
,3
,4
]}

Petraviciene, Inga ^{[7
]}

Robinson, Oliver ^{[2
,11
]}

Roumeliotaki, Theano ^{[10
]}

Sunyer, Jordi ^{[2
,3
,4
]}

Tamayo-Uria, Ibon ^{[2
,3
,4
]}

Thomsen, Cathrine ^{[5
]}

Urquiza, Jose ^{[2
,3
,4
]}

Valentin, Antonia ^{[2
,3
,4
]}

Slama, Remy ^{[1
]}

Vrijheid, Martine ^{[2
,3
,4
]}

Siroux, Valerie ^{[1
]}

机构：

[1] Univ Grenoble Alpes, Team Environm Epidemiol Appl Reprod & Resp Hlth, INSERM, CNRS,IAB,U1209,Joint Res Ctr, Grenoble, France

[2] ISGlobal, Barcelona, Spain

[3] UPF, Barcelona, Spain

[4] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain

[5] Norwegian Inst Publ Hlth, Oslo, Norway

[6] Bradford Teaching Hosp NHS Fdn Trust, Bradford Inst Hlth Res, Bradford, W Yorkshire, England

[7] Vytautas Magnus Univ, Dept Environm Sci, Kaunas, Lithuania

[8] Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90007 USA

[9] Univ Crete, Dept Social Med, Iraklion, Greece

[10] Maastricht Univ, Fac Hlth Med & Life Sci, Dept Genet & Cell Biol, Maastricht, Netherlands

[11] Imperial Coll London, Sch Publ Hlth, MRC PHE Ctr Environm & Hlth, London, England

来源：

LANCET PLANETARY HEALTH | 2019年 / 3卷 / 02期

关键词：

RESPIRATORY-TRACT INFECTIONS; PRENATAL EXPOSURE; NEIGHBORHOOD WALKABILITY; AIR-POLLUTION; HEALTH; ASTHMA; AGE; ASSOCIATION; POLLUTANTS; INFANCY;

D O I：

10.1016/S2542-5196(19)30010-5

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Background Several single-exposure studies have documented possible effects of environmental factors on lung function, but none has relied on an exposome approach. We aimed to evaluate the association between a broad range of prenatal and postnatal lifestyle and environmental exposures and lung function in children. Methods In this analysis, we used data from 1033 mother-child pairs from the European Human Early-Life Exposome (HELIX) cohort (consisting of six existing longitudinal birth cohorts in France, Greece, Lithuania, Norway, Spain, and the UK of children born between 2003 and 2009) for whom a valid spirometry test was recorded for the child. 85 prenatal and 125 postnatal exposures relating to outdoor, indoor, chemical, and lifestyle factors were assessed, and lung function was measured by spirometry in children at age 6-12 years. Two agnostic linear regression methods, a deletion-substitution-addition (DSA) algorithm considering all exposures simultaneously, and an exposome-wide association study (ExWAS) considering exposures independently, were applied to test the association with forced expiratory volume in 1 s percent predicted values (FEV1%). We tested for two-way interaction between exposures and corrected for confounding by co-exposures. Findings In the 1033 children (median age 8.1 years, IQR 6.5-9.0), mean FEV1% was 98.8% (SD 13.2). In the ExWAS, prenatal perfluorononanoate (p=0.034) and perfluorooctanoate (p=0.030) exposures were associated with lower FEV1%, and inverse distance to nearest road during pregnancy (p=0.030) was associated with higher FEV1%. Nine postnatal exposures were associated with lower FEV1%: copper (p=0.041), ethyl-paraben (p=0.029), five phthalate metabolites (mono-2-ethyl 5-carboxypentyl phthalate [p=0.016], mono-2-ethyl-5-hydroxyhexyl phthalate [p=0.023], mono-2-ethyl-5-oxohexyl phthalate [p=0.0085], mono-4-methyl-7-oxooctyl phthalate [p=0.040], and the sum of di-ethylhexyl phthalate metabolites [p=0.014]), house crowding (p=0.015), and facility density around schools (p=0.027). However, no exposure passed the significance threshold when corrected for multiple testing in ExWAS, and none was selected with the DSA algorithm, including when testing for exposure interactions. Interpretation Our systematic exposome approach identified several environmental exposures, mainly chemicals, that might be associated with lung function. Reducing exposure to these ubiquitous chemicals could help to prevent the development of chronic respiratory disease. Copyright (C) The Author(s). Published by Elsevier Ltd.

引用

页码：E81 / E92

页数：12

共 46 条

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