Stem Cells from Human Exfoliated Deciduous Teeth: A Concise Review

被引：29

作者：

Ko, Chih-Sheng ^{[1
]}

Chen, Jen-Hao ^{[2
,3
]}

Su, Wen-Ta ^{[4
]}

机构：

[1] PhytoHlth Corp, Taipei, Taiwan

[2] Kaohsiung Med Univ, Coll Dent Med, Sch Dent, Kaohsiung, Taiwan

[3] Kaohsiung Med Univ Hosp, Prosthodont Dept, Kaohsiung, Taiwan

[4] Natl Taipei Univ Technol, Dept Chem Engn & Biotechnol, Taipei, Taiwan

来源：

CURRENT STEM CELL RESEARCH & THERAPY | 2020年 / 15卷 / 01期

关键词：

Stem cells from human exfoliated deciduous teeth; dental stem cells; isolation; banking; ESCs; HSCs; SPINAL-CORD-INJURY; HUMAN BONE-MARROW; DENTAL-PULP CELLS; OSTEOGENIC DIFFERENTIATION; IN-VITRO; CONDITIONED MEDIUM; OSTEOBLASTIC DIFFERENTIATION; STEM/PROGENITOR CELLS; THERAPEUTIC BENEFITS; SHED DIFFERENTIATE;

D O I：

10.2174/1574888X14666191018122109

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Stem Cells from Human Exfoliated Deciduous Teeth (SHED) originate from the embryonic neural crest as ectodermal mesenchymal stem cells and are isolated from human deciduous teeth. SHED expresses the same cell markers as Embryonic Stem Cells (ESCs), such as OCT4 and NANOG, which make SHED to have a significant impact on clinical applications. SHED possess higher rates of proliferation, higher telomerase activity, increased cell population doubling, form sphere-like clusters, and possess immature and multi-differentiation capacity; such high plasticity makes SHED one of the most popular sources of stem cells for biomedical engineering. In this review, we describe the isolation and banking method, the current development of SHED in regenerative medicine and tissue engineering in vitro and in vivo.

引用

页码：61 / 76

页数：16

共 137 条

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