Defining the human immunodeficiency virus type 1 transmission genetic bottleneck in a region with multiple circulating subtypes and recombinant forms

被引：9

作者：

Nofemela, Andile ^{[1
]}

Bandawe, Gama ^{[1
]}

Thebus, Ruwayhida ^{[1
]}

Marais, Jinny ^{[1
]}

Wood, Natasha

Hoffmann, Oliver ^{[4
]}

Maboko, Leonard ^{[3
]}

Hoelscher, Michael ^{[3
,4
]}

Woodman, Zenda ^{[2
]}

Williamson, Carolyn ^{[1
]}

机构：

[1] Univ Cape Town, Inst Infect Dis & Mol Med, Div Med Virol, Fac Hlth Sci, ZA-7925 Observatory, South Africa

[2] Univ Cape Town, Dept Mol & Cell Biol, ZA-7925 Cape Town, South Africa

[3] Minist Hlth, NIMR Mbeya Med Res Programme, Mbeya, Tanzania

[4] Klinikum Ludwig Maximilians Univ, Dept Infect Dis & Trop Med, Munich, Germany

来源：

VIROLOGY | 2011年 / 415卷 / 02期

关键词：

HIV; Genetic variability; Transmission; Bottleneck; Mbeya; MBEYA REGION; DISEASE PROGRESSION; HIV-1; SUBTYPE; INFECTION; DIVERSIFICATION; VIREMIA;

D O I：

10.1016/j.virol.2010.12.027

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Mbeya region of Tanzania has a genetically complex HIV epidemic with multiple subtypes and recombinant forms circulating, together with a high frequency of dual infections with more than one subtype. This study aimed to determine whether this impacted the HIV-1 transmission bottleneck. A total of 210 env sequences from 22 participants were generated from recently infected women from Mbeya using the single genome amplification approach. Participants were infected with subtypes C (n = 9), A (n = 4), or D (n = 1), and recombinants AC (n = 4), CD (n = 2), AD (n = 1), or ACD (n = 1). Sixteen participants (73%) were infected with a single variant; five (23%) with multiple variants; and one (4%) was dually infected. Thus the frequency of single variant infections was similar to cohorts located in genetically restricted subtype B or C epidemics, suggesting that multiple circulating subtypes and unique recombinant forms do not have a significant impact on the transmission bottleneck. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：107 / 113

页数：7

共 22 条

[1] Quantitating the Multiplicity of Infection with Human Immunodeficiency Virus Type 1 Subtype C Reveals a Non-Poisson Distribution of Transmitted Variants [J].

Abrahams, M. -R. ;

Anderson, J. A. ;

Giorgi, E. E. ;

Seoighe, C. ;

Mlisana, K. ;

Ping, L. -H. ;

Athreya, G. S. ;

Treurnicht, F. K. ;

Keele, B. F. ;

Wood, N. ;

Salazar-Gonzalez, J. F. ;

Bhattacharya, T. ;

Chu, H. ;

Hoffman, I. ;

Galvin, S. ;

Mapanje, C. ;

Kazembe, P. ;

Thebus, R. ;

Fiscus, S. ;

Hide, W. ;

Cohen, M. S. ;

Karim, S. Abdool ;

Haynes, B. F. ;

Shaw, G. M. ;

Hahn, B. H. ;

Korber, B. T. ;

Swanstrom, R. ;

Williamson, C. .

JOURNAL OF VIROLOGY, 2009, 83 (08) :3556-3567

[2] HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loads [J].

Baeten, Jared M. ;

Chohan, Bhavna ;

Lavreys, Ludo ;

Chohan, Vrasha ;

McClelland, R. Scott ;

Certain, Laura ;

Mandaliya, Kishorchandra ;

Jaoko, Walter ;

Overbaugh, Julie .

JOURNAL OF INFECTIOUS DISEASES, 2007, 195 (08) :1177-1180

[3] Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission [J].

Derdeyn, CA ;

Decker, JM ;

Bibollet-Ruche, F ;

Mokili, JL ;

Muldoon, M ;

Denham, SA ;

Heil, ML ;

Kasolo, F ;

Musonda, R ;

Hahn, BH ;

Shaw, GM ;

Korber, BT ;

Allen, S ;

Hunter, E .

SCIENCE, 2004, 303 (5666) :2019-2022

[4] Inference of viral evolutionary rates from molecular sequences [J].

Drummond, A ;

Pybus, OG ;

Rambaut, A .

ADVANCES IN PARASITOLOGY, VOL 54: THE EVOLUTION OF PARASITISM-A PHYLOGENETIC PERSPECTIVE, 2003, 54 :331-358

[5] BEAST: Bayesian evolutionary analysis by sampling trees [J].

Drummond, Alexei J. ;

Rambaut, Andrew .

BMC EVOLUTIONARY BIOLOGY, 2007, 7 (1)

[6] Relaxed phylogenetics and dating with confidence [J].

Drummond, Alexei J. ;

Ho, Simon Y. W. ;

Phillips, Matthew J. ;

Rambaut, Andrew .

PLOS BIOLOGY, 2006, 4 (05) :699-710

[7] Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection [J].

Fiebig, EW ;

Wright, DJ ;

Rawal, BD ;

Garrett, PE ;

Schumacher, RT ;

Peddada, L ;

Heldebrant, C ;

Smith, R ;

Conrad, A ;

Kleinman, SH ;

Busch, MP .

AIDS, 2003, 17 (13) :1871-1879

[8] CD8 T-cell recognition of multiple epitopes within specific gag regions is associated with maintenance of a low steady-state viremia in human immunodeficiency virus type 1-seropositive patients [J].

Geldmacher, Christof ;

Currier, Jeffrey R. ;

Herrmann, Eva ;

Haule, Antelmo ;

Kuta, Ellen ;

McCutchan, Francine ;

Njovu, Lilian ;

Geis, Steffen ;

Hoffmann, Oliver ;

Maboko, Leonard ;

Williamson, Carolyn ;

Birx, Deborah ;

Meyerhans, Andreas ;

Cox, Josephine ;

Hoelscher, Michael .

JOURNAL OF VIROLOGY, 2007, 81 (05) :2440-2448

[9] Inflammatory Genital Infections Mitigate a Severe Genetic Bottleneck in Heterosexual Transmission of Subtype A and C HIV-1 [J].

Haaland, Richard E. ;

Hawkins, Paulina A. ;

Salazar-Gonzalez, Jesus ;

Johnson, Amber ;

Tichacek, Amanda ;

Karita, Etienne ;

Manigart, Olivier ;

Mulenga, Joseph ;

Keele, Brandon F. ;

Shaw, George M. ;

Hahn, Beatrice H. ;

Allen, Susan A. ;

Derdeyn, Cynthia A. ;

Hunter, Eric .

PLOS PATHOGENS, 2009, 5 (01)

[10] Frequency of HIV type 1 dual infection and HIV diversity: Analysis of low- and high-risk populations in Mbeya Region, Tanzania [J].

Herbinger, Karl-Heinz ;

Gerhardt, Martina ;

Piyasirisilp, Sucheep ;

Mloka, Doreen ;

Arroyo, Miguel A. ;

Hoffmann, Oliver ;

Maboko, Leonard ;

Birx, Deborah L. ;

Mmbando, Donan ;

McCutchan, Francine E. ;

Hoelscher, Michael .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2006, 22 (07) :599-606

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