Understanding the finite state projection and related methods for solving the chemical master equation

被引:18
|
作者
Dinh, Khanh N. [1 ]
Sidje, Roger B. [1 ]
机构
[1] Univ Alabama, Dept Math, Tuscaloosa, AL 35487 USA
基金
美国国家科学基金会;
关键词
ODE solver; chemical master equation; gene regulation; finite state projection; ACCELERATED STOCHASTIC SIMULATION; MODELS;
D O I
10.1088/1478-3975/13/3/035003
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The finite state projection (FSP) method has enabled us to solve the chemical master equation of some biological models that were considered out of reach not long ago. Since the original FSP method, much effort has gone into transforming it into an adaptive time-stepping algorithm as well as studying its accuracy. Some of the improvements include the multiple time interval FSP, the sliding windows, and most notably the Krylov-FSP approach. Our goal in this tutorial is to give the reader an overview of the current methods that build on the FSP.
引用
收藏
页数:13
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