The role of tumor necrosis factor receptor type 1 in orthodontic tooth movement

被引：71
作者：
Andrade, I., Jr.
Silva, T. A.
Silva, G. A. B.
Teixeira, A. L.
Teixeira, M. M.
机构：
[1] Univ Fed Minas Gerais, Fac Dent, Dept Oral Pathol, BR-31270901 Belo Horizonte, MG, Brazil
[2] Pontificia Univ Catolica Minas Gerais PUC Minas, Dept Orthodont, Fac Dent, Belo Horizonte, MG, Brazil
[3] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Morphol, Belo Horizonte, MG, Brazil
[4] Univ Fed Minas Gerais, Fac Med, Dept Clin Med, Belo Horizonte, MG, Brazil
[5] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Biochem & Immunol, Belo Horizonte, MG, Brazil
来源：
JOURNAL OF DENTAL RESEARCH | 2007年 / 86卷 / 11期
关键词：
orthodontic tooth movement; mechanical loading; bone remodeling; TNF-alpha; chemokines;
D O I：
10.1177/154405910708601113
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Orthodontic tooth movement is dependent on osteoclast activity. Tumor necrosis factor (TNF)-alpha plays an important role, directly or via chemokine release, in osteoclast recruitment and activation. This study aimed to investigate whether the TNF receptor type 1 (p55) influences these events and, consequently, orthodontic tooth movement. An orthodontic appliance was placed in wild-type mice (WT) and p55-deficient mice (p55(-/-)). Levels of TNF-alpha and 2 chemokines (MCP-1/CCL2, RANTES/CCL5) were evaluated in periodontal tissues. A significant increase in CCL2 and TNF-alpha was observed in both groups after 12 hrs of mechanical loading. However, CCL5 levels remained unchanged in p55(-/-) mice at this time-point. The number of TRAP-positive osteoclasts in p55(-/-) mice was significantly lower than that in WT mice. Also, there was a significantly smaller rate of tooth movement in p55(-/-) mice. Analysis of our data suggests that the TNFR-1 plays a significant role in orthodontic tooth movement that might be associated with changes in CCL5 levels.
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收藏
页码：1089 / 1094
页数：6
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