Improved analytical sensitivity reveals the occurrence of gender-related variability in diamine oxidase enzyme activity in healthy individuals

被引：32
作者：
Garcia-Martin, Elena
Ayuso, Pedro
Martinez, Carmen
Agundez, Jose A. G.
机构：
[1] Univ Extremadura, Sch Biol Sci, Dept Biochem & Mol Biol, Badajoz 06071, Spain
[2] Univ Extremadura, Sch Med, Dept Pharmacol, Badajoz, Spain
来源：
CLINICAL BIOCHEMISTRY | 2007年 / 40卷 / 16-17期
关键词：
diamine oxidase; DAO; ABP1; gender; healthy;
D O I：
10.1016/j.clinbiochem.2007.07.019
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Objectives: Serum diamine oxidase (DAO; EC 1.4.3.6) activity is often employed as a clinical indicator of the integrity of intestinal mucosa. However, interindividual variation in enzyme activity and reference values for healthy women and men have not been studied. Design and methods: DAO activity was measured by using cadaverine coupled to O-dianisidine oxidation in 50 healthy individuals. Results: The mean activity was 7.59 +/- 3.67 U/L for women and 2.38 +/- 0.71 U/L for men (0<0.00l). Conclusions: Gender is a major determinant for DAO activity in healthy subjects. (C) 2007 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
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收藏
页码：1339 / 1341
页数：3
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