CMIP promotes Herceptin resistance of HER2 positive gastric cancer cells

被引：7
作者：
Xiang, Ru [1 ]
Han, Xiaowen [2 ]
Ding, Keshuo [2 ]
Wu, Zhengsheng [2 ]
机构：
[1] Anhui Med Univ, Sch Nursing, Hefei 230032, Anhui, Peoples R China
[2] Anhui Med Univ, Sch Basic Med, Dept Pathol, Hefei 230032, Anhui, Peoples R China
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2020年 / 216卷 / 02期
关键词：
CMIP; SOX2; Herceptin resistance; Gastric cancer; TRASTUZUMAB RESISTANCE; EXPRESSION; TRANSCRIPTION; PROTEIN; SOX2;
D O I：
10.1016/j.prp.2019.152776
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Gastric cancer remains one of the most malignant human cancers with poor prognosis. Herceptin is a well-received antibody drug for HER2 positive gastric cancer. Primary Herceptin resistance and acquired Herceptin resistance retarded the use of Herceptin for gastric cancer. We herein reported CMIP (C-Maf-inducing protein) was overexpressed in Herceptin-resistant gastric cancer cells MKN45-HR and NCI-N87-HR; CMIP promoted Herceptin resistance of HER2 positive gastric cancer cells. SOX2 was examined to be positively regulated by CMIP and also promoted Herceptin resistance of HER2 positive gastric cancer cells. SOX2 might mediate the Herceptin resistance promoting role of CMIP in gastric cancer cells. Elevated expression of CMIP was associated with poor clinicopathological features including tumor size, lymph node metastasis and clinical stage in HER2 positive gastric cancer patients. Inhibitors of CMIP could be used as potential adjuvant therapeutic drugs for HER2 positive gastric cancer.
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页数：8
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