Genome-wide association study of childhood acute lymphoblastic leukemia in Korea

被引：48

作者：

Han, Sohee ^{[1
]}

Lee, Kyoung-Mu ^{[1
,2
]}

Park, Sue K. ^{[1
,3
,9
]}

Lee, Jong Eun ^{[4
]}

Ahn, Hyo Seop ^{[5
,9
]}

Shin, Hee Young ^{[5
,9
]}

Kang, Hyoung Jin ^{[5
,9
]}

Koo, Hong Hoe ^{[6
,9
]}

Seo, Jong Jin ^{[7
]}

Choi, Ji Eun ^{[8
]}

Ahn, Yoon-Ok ^{[1
]}

Kang, Daehee ^{[1
,9
,10
,11
,12
]}

机构：

[1] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul 110799, South Korea

[2] Seoul Natl Univ Hosp, Clin Res Inst, Seoul 110744, South Korea

[3] Seoul Natl Univ, Inst Hlth Polit & Management, Seoul 110799, South Korea

[4] DNA Link Inc, Seoul, South Korea

[5] Seoul Natl Univ, Coll Med, Dept Pediat, Seoul 110799, South Korea

[6] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pediat, Seoul, South Korea

[7] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pediat, Seoul, South Korea

[8] Seoul Metropolitan Boramae Hosp, Dept Pediat, Seoul, South Korea

[9] Seoul Natl Univ, Canc Res Inst, Seoul 110799, South Korea

[10] Seoul Natl Univ, Coll Med, Seoul 110799, South Korea

[11] Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Dept Mol Med & Biopharmaceut Sci, Seoul 110799, South Korea

[12] Seoul Natl Univ, Coll Pharm, Seoul 110799, South Korea

来源：

LEUKEMIA RESEARCH | 2010年 / 34卷 / 10期

关键词：

Childhood acute lymphoblastic leukemia (ALL); Genome-wide association study (GWAS); Single nucleotide polymorphism (SNP); GENES; RISK; POLYMORPHISMS; VARIANTS; DISEASE;

D O I：

10.1016/j.leukres.2010.02.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We conducted a genome-wide association study of childhood acute lymphoblastic leukemia (ALL) in a case-control study conducted in Korea. Incident childhood ALL cases (n = 50) and non-cancer controls (n = 50) frequency-matched to cases by age and sex, recruited from three teaching hospitals in Seoul between 2003 and 2008, were genotyped using Affymetrix SNP Array 6.0 platform. ALL risks were estimated as odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for age and birth weight. The false discovery rate (FDR) was used for adjusting multiple tests. Of these 1 million SNPs, six SNPs in 4 genes (HA01 rs6140264, EPB41L2 rs9388856, rs9388857, rs1360756, C2orf3 12105972, MAN2A1 rs3776932) were strongly associated with childhood ALL risk (P(dominant) <= 0.0001 and P(trend) <0.006). These SNPs remained significant after FDR adjustment (FDR value <0.2). Our genome-wide association study in Korea children identified a few genetic variations as potential susceptibility markers for ALL, warranting further replication studies among various ethnic groups. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1271 / 1274

页数：4

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