Danish study of a Modified Atkins diet for medically intractable epilepsy in children: Can we achieve the same results as with the classical ketogenic diet?

被引:60
作者
Miranda, Maria J. [1 ,2 ]
Mortensen, Mette [3 ]
Povlsen, Jane H. [3 ]
Nielsen, Helle [3 ]
Beniczky, Sandor [4 ,5 ]
机构
[1] Danish Epilepsy Ctr, Dept Paediat, Filadelfia, Dianalund, Denmark
[2] Glostrup Univ Hosp, Dept Paediat, Glostrup, Denmark
[3] Danish Epilepsy Ctr, Ketogen Diet Team, Filadelfia, Dianalund, Denmark
[4] Danish Epilepsy Ctr, Dept Clin Neurophysiol, Filadelfia, Dianalund, Denmark
[5] Univ So Denmark, Inst Reg Hlth Serv Res, Odense, Denmark
来源
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY | 2011年 / 20卷 / 02期
关键词
Modified Atkins diet; Medically intractable epilepsy; Comparison; Ketogenic diet; REFRACTORY EPILEPSY; PEDIATRIC EPILEPSY; CHILDHOOD EPILEPSY; EFFICACY; THERAPY; ADULTS; TRIAL;
D O I
10.1016/j.seizure.2010.11.010
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Modified Atkins diet (MAD) is a less restrictive variety of the classical ketogenic diet (KD), used for treating patients with medically resistant epilepsy. There are only few reports comparing the two types of diets in terms of seizure reduction and tolerability. We compared the effect of a MAD evaluated prospectively on 33 consecutive children with medically resistant epilepsy, with a group of 50 patients, previously treated with KD. Patients who had >50% seizure reduction were considered responders. After 3 months on the MAD, 17 patients (52%) were responders, including 14 (42%) who had >90% seizure reduction. After 6 months, 13 patients (39%) were responders. Seventeen patients (52%) remained on the MAD at least 12 months with excellent overall tolerance and compliance, including 9 patients (27%) who were responders, 4 of them (12%) having >90% seizure reduction. Although there was a trend for higher incidence of responders in the KD group, this failed to reach the level of significance: after 6 months 39% on MAD and 60% on KID were responders. However, this trend was not observed when the two groups were adjusted for difference in age (patients in the MAD group were older than the KD group). In conclusion, our experience suggests that the MAD is similarly effective as the KD in reducing seizure frequency in children with medically resistant epilepsy. (C) 2010 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:151 / 155
页数:5
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