Erythrocyte Membrane Camouflaged Metal-Organic Framework Nanodrugs for Remodeled Tumor Microenvironment and Enhanced Tumor Chemotherapy

被引：49

作者：

Qiao, Chaoqiang ^{[1
]}

Wang, Xiaofei ^{[1
]}

Liu, Guohuan ^{[1
]}

Yang, Zuo ^{[1
]}

Jia, Qian ^{[1
]}

Wang, Lexuan ^{[1
]}

Zhang, Ruili ^{[1
]}

Xia, Yuqiong ^{[1
]}

Wang, Zhongliang ^{[1
,2
]}

Yang, Yang ^{[3
,4
]}

机构：

[1] Xidian Univ, Lab Mol Imaging & Translat Med MITM, Engn Res Ctr Mol & Neuroimaging, Minist Educ,Sch Life Sci & Technol, Xian 710126, Shaanxi, Peoples R China

[2] Xidian Univ, Acad Adv Interdisciplinary Res, Xian 710071, Shaanxi, Peoples R China

[3] Tongji Univ, Dept Thorac Surg, Shanghai Pulm Hosp, Sch Med, Shanghai 200433, Peoples R China

[4] Tongji Univ, Sch Mat Sci & Engn, Shanghai 201804, Peoples R China

来源：

ADVANCED FUNCTIONAL MATERIALS | 2022年 / 32卷 / 06期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

chemotherapy; metal-organic framework; red blood cell membrane; transforming growth factor beta; tumor microenvironment normalization; TGF-BETA; DELIVERY; NANOMEDICINE; THERAPY; NANOPARTICLES; THERAPEUTICS; PENETRATION; STRATEGIES; RESISTANCE; CARCINOMA;

D O I：

10.1002/adfm.202107791

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The abundant extracellular matrix (ECM) in solid tumors causes limited drug penetration and hypoxia-mediated chemoresistance, which lead to poor chemotherapy outcomes. To solve this problem, a biomimetic metal-organic framework nanodrug (ZIF-8-DOX-LY-RM) is developed with red blood cell membrane (RM) camouflage and encapsulation of type 1 transforming growth factor beta receptor (TGFBR1) inhibitor and doxorubicin (DOX) for efficient chemotherapy. Based on the biomimetic properties of the erythrocyte membrane, ZIF-8-DOX-LY-RM can effectively accumulate in tumor tissues with immune escape and prolonged blood circulation. Then, the enriched nanodrug ZIF-8-DOX-LY-RM releases the TGFBR1 to remove collagen, subsequently leading to enhanced nanodrug penetration and increased oxygen supply. The abundant oxygen supply then relieves hypoxia-mediated chemoresistance of DOX through increased cellular uptake and elevated reactive oxygen species production. The in vivo studies demonstrate the outstanding performance of ZIF-8-DOX-LY-RM nanoparticles in chemotherapy of cancer. This work presents an ECM normalization strategy for the synergistic collagen depletion and hypoxia alleviation and opens a promising avenue for effective chemotherapy of solid tumors.

引用

页数：11

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