A Top-Down Cortical Circuit for Accurate Sensory Perception

被引：260

作者：

Manita, Satoshi ^{[1
]}

Suzuki, Takayuki ^{[1
]}

Homma, Chihiro ^{[1
]}

Matsumoto, Takashi ^{[1
]}

Odagawa, Maya ^{[1
]}

Yamada, Kazuyuki ^{[1
]}

Ota, Keisuke ^{[1
,2
]}

Matsubara, Chie ^{[1
]}

Inutsuka, Ayumu ^{[3
]}

Sato, Masaaki ^{[4
,5
]}

Ohkura, Masamichi ^{[6
,7
]}

Yamanaka, Akihiro ^{[3
]}

Yanagawa, Yuchio ^{[8
]}

Nakai, Junichi ^{[6
,7
]}

Hayashi, Yasunori ^{[4
,6
,7
]}

Larkum, Matthew E. ^{[9
]}

Murayama, Masanori ^{[1
]}

机构：

[1] RIKEN, Lab Behav Neurophysiol, Brain Sci Inst, Wako, Saitama 3510198, Japan

[2] JSPS, Chiyoda Ku, Tokyo 1020083, Japan

[3] Nagoya Univ, Environm Med Res Inst, Dept Neurosci 2, Chikusa Ku, Nagoya, Aichi 4648601, Japan

[4] RIKEN, Brain Sci Inst, Wako, Saitama 3510198, Japan

[5] Japan Sci & Technol Agcy, PRESTO, Kawaguchi, Saitama 3320012, Japan

[6] Saitama Univ, Grad Sch Sci & Engn, Sakura Ku, Saitama, Saitama 3388570, Japan

[7] Saitama Univ, Brain Sci Inst, Sakura Ku, Saitama, Saitama 3388570, Japan

[8] Gunma Univ, Grad Sch Med, Dept Genet & Behav Neurosci, Maebashi, Gunma 3718511, Japan

[9] Humboldt Univ, NeuroCure Cluster Excellence, D-10117 Berlin, Germany

来源：

NEURON | 2015年 / 86卷 / 05期

基金：

日本学术振兴会; 日本科学技术振兴机构;

关键词：

MEDIAL AGRANULAR CORTEX; PREFRONTAL CORTEX; CELLULAR MECHANISM; MOTOR CORTEX; CONNECTIONS; FEEDBACK; PROJECTIONS; MODULATION; INTEGRATION; ATTENTION;

D O I：

10.1016/j.neuron.2015.05.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A fundamental issue in cortical processing of sensory information is whether top-down control circuits from higher brain areas to primary sensory areas not only modulate but actively engage in perception. Here, we report the identification of a neural circuit for top-down control in the mouse somatosensory system. The circuit consisted of a long-range reciprocal projection between M2 secondary motor cortex and S1 primary somatosensory cortex. In vivo physiological recordings revealed that sensory stimulation induced sequential S1 to M2 followed by M2 to S1 neural activity. The top-down projection from M2 to S1 initiated dendritic spikes and persistent firing of S1 layer 5 (L5) neurons. Optogenetic inhibition of M2 input to S1 decreased L5 firing and the accurate perception of tactile surfaces. These findings demonstrate that recurrent input to sensory areas is essential for accurate perception and provide a physiological model for one type of top-down control circuit.

引用

页码：1304 / 1316

页数：13

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