A pathway and genetic factors contributing to elevated gene expression noise in stationary phase

被引：17

作者：

Guido, Nicholas J.

Lee, Philina

Wang, Xiao

Elston, Timothy C.

Collins, J. J. ^{[1
]}

机构：

[1] Boston Univ, Dept Biomed Engn, Ctr BioDynamics, Boston, MA 02215 USA

[2] Univ N Carolina, Dept Pharmacol, Chapel Hill, NC USA

来源：

BIOPHYSICAL JOURNAL | 2007年 / 93卷 / 11期

关键词：

D O I：

10.1529/biophysj.107.118687

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Previous studies have identified factors associated with transcription and translation efficiency, such as promoter strength and mRNA sequences, that can affect stochasticity in gene expression. Here we present evidence for a pathway and associated genetic factors ( namely, the ribosome modulation factor RMF and ppGpp) in Escherichia coli that contribute to heightened levels of gene expression noise during stationary phase. Endogenous cellular mechanisms that globally affect gene expression noise, such as those identified in this study, could provide phenotypic diversity under adverse conditions such as stationary phase.

引用

收藏

页码：L55 / L57

页数：3

相关论文

共 18 条

[1] Modulation of mRNA stability participates in stationary-phase-specific expression of ribosome modulation factor [J].

Aiso, T ;

Yoshida, H ;

Wada, A ;

Ohki, R .

JOURNAL OF BACTERIOLOGY, 2005, 187 (06) :1951-1958

[2] Engineering stability in gene networks by autoregulation [J].

Becskei, A ;

Serrano, L .

NATURE, 2000, 405 (6786) :590-593

[3] Stress-induced mutagenesis in bacteria [J].

Bjedov, I ;

Tenaillon, O ;

Gérard, B ;

Souza, V ;

Denamur, E ;

Radman, M ;

Taddei, F ;

Matic, I .

SCIENCE, 2003, 300 (5624) :1404-1409

[4] Phenotypic consequences of promoter-mediated transcriptional noise [J].

Blake, William J. ;

Balazsi, Gbor ;

Kohanski, Michael A. ;

Isaacs, Farren J. ;

Murphy, Kevin F. ;

Kuang, Yina ;

Cantor, Charles R. ;

Walt, David R. ;

Collins, James J. .

MOLECULAR CELL, 2006, 24 (06) :853-865

[5]

CASHEL M, 2006, STRINGENT RESPONSE, pCH92

[6] A synthetic oscillatory network of transcriptional regulators [J].

Elowitz, MB ;

Leibler, S .

NATURE, 2000, 403 (6767) :335-338

[7] Stress responses and genetic variation in bacteria [J].

Foster, PL .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2005, 569 (1-2) :3-11

[8] A bottom-up approach to gene regulation [J].

Guido, NJ ;

Wang, X ;

Adalsteinsson, D ;

McMillen, D ;

Hasty, J ;

Cantor, CR ;

Elston, TC ;

Collins, JJ .

NATURE, 2006, 439 (7078) :856-860

[9] Adaptive mutation and amplification in Escherichia coli:: two pathways of genome adaptation under stress [J].

Hersh, MN ;

Ponder, RG ;

Hastings, PJ ;

Rosenberg, SM .

RESEARCH IN MICROBIOLOGY, 2004, 155 (05) :352-359

[10] Ultrasensitivity and noise propagation in a synthetic transcriptional cascade [J].

Hooshangi, S ;

Thiberge, S ;

Weiss, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (10) :3581-3586