Withanolides and aromatic glycosides isolated from Nicandra physaloides and their anti-inflammatory activity

被引：16

作者：

Zhang, Peng ^{[1
]}

Wu, Yan-Li ^{[1
]}

Niu, Ying-Xue ^{[1
]}

Li, Zhen-Li ^{[1
]}

Zhu, Li-Han ^{[1
]}

Li, Hua ^{[1
,2
]}

Chen, Li-Xia ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Minist Educ, Wuya Coll Innovat, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Wuhan 430030, Hubei, Peoples R China

来源：

FITOTERAPIA | 2018年 / 131卷

基金：

中国国家自然科学基金;

关键词：

Nicandra physaloides; Withanolides; Aromatic glycosides; NO inhibitory activity; ANTIFEEDANT ACTIVITY; LEAVES; STEMS;

D O I：

10.1016/j.fitote.2018.11.003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new withanolides (1-2) together with five known ones (3-7), and three known aromatic glycosides (8-10) were isolated from the dried stems and leaves of Nicandra physaloides, an edible and medicinal plant. Their structures were identified by extensive spectroscopic analyses or comparison with literature data. The absolute configuration of 2 was assigned via X-ray crystallography. Compound 1 with a spiroketal moiety is relatively unusual in withanolides. Aromatic glycosides (8-10) showed potent inhibitory activity against LPS-induced nitric oxide production in RAW 264.7 macrophages, with IC50 values from 4.69 to 16.12 mu M.

引用

页码：260 / 264

页数：5

共 23 条

[1] Withanolides from Physalis hispida [J].

Cao, Cong-Mei ;

Zhang, Huaping ;

Gallagher, Robert J. ;

Day, Victor W. ;

Kindscher, Kelly ;

Grogan, Patrick ;

Cohen, Mark S. ;

Timmermann, Barbara N. .

JOURNAL OF NATURAL PRODUCTS, 2014, 77 (03) :631-639

[2]

Cardona Diana, 2005, Actualidades Biologicas (Medellin), V27, P81

[3] Nitric oxide - A novel therapeutic for cancer [J].

Coulter, J. A. ;

McCarthy, H. O. ;

Xiang, J. ;

Roedl, W. ;

Wagner, E. ;

Robson, T. ;

Hirst, D. G. .

NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2008, 19 (02) :192-198

[4] Metabolite Profiling of Sugarcane Genotypes and Identification of Flavonoid Glycosides and Phenolic Acids [J].

Coutinho, Isabel D. ;

Baker, John M. ;

Ward, Jane L. ;

Beale, Michael H. ;

Creste, Silvana ;

Cavalheiro, Alberto J. .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2016, 64 (21) :4198-4206

[5] MAPK signalling pathways as molecular targets for anti-inflammatory therapy - from molecular mechanisms to therapeutic benefits [J].

Kaminska, B .

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2005, 1754 (1-2) :253-262

[6] Hydrolysis of β-galactosyl ester linkage by β-galactosidases [J].

Kiso, T ;

Nakano, H ;

Nakajima, H ;

Terai, T ;

Okamoto, K ;

Kitahata, S .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2000, 64 (08) :1702-1706

[7]

Kshirsagar P.P., 2015, International Journal of Current Pharmaceutical Research, V7, P60

[8]

Li S. C., 2000, SPECIAL EC ANIMAL PL, V6, P21

[9] Complementary and alternative medicine: Herbs, phytochemicals and vitamins and their immunologic effects [J].

Mainardi, Timothy ;

Kapoor, Simi ;

Bielory, Leonard .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 123 (02) :283-294

[10] Antifeedant activity of withanolides from Salpichroa origanifolia on Musca domestica [J].

Mareggiani, G ;

Picollo, MI ;

Zerba, E ;

Burton, G ;

Tettamanzi, MC ;

Benedetti-Doctorovich, MOV ;

Veleiro, AS .

JOURNAL OF NATURAL PRODUCTS, 2000, 63 (08) :1113-1116

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