Vagus nerve stimulation and the postictal state

被引:9
作者
Vonck, Kristl [1 ]
Raedt, Robrecht [1 ]
Boon, Paul [1 ]
机构
[1] Ghent Univ Hosp, Reference Ctr Refactory Epilepsy, Lab Clin & Expt Neurophysiol, Dept Neurol, B-9000 Ghent, Belgium
关键词
Refractory epilepsy; Neurostimulation; Vagus nerve stimulation; Postictal state; EPILEPSY; BRAIN; SEIZURES; THERAPY; MOOD; IMMUNOREACTIVITY; INVOLVEMENT; INDUCTION; ADENOSINE; FOS;
D O I
10.1016/j.yebeh.2010.06.020
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Vagus nerve stimulation (VNS) is an established neurostimulation therapy used to treat refractory epilepsy. The effect of acute or chronic VNS on the postictal state as a separate entity is seldom reported in clinical or experimental studies. Apart from its antiseizure effects. VNS has several other beneficial effects. These effects may be of particular benefit for patients with postictal neuropsychiatric symptoms. The hypothesized mechanisms underlying the initiation and sustainment of the postictal phase, to some extent, overlap with mechanisms involved in the seizure-suppressing effects of VNS as well as other neurological and psychotropic effects of VNS. Both the clinical symptoms and the basic research hypotheses of the postictal state show similarities with clinical effects induced by VNS and its underlying mechanisms of action. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:182 / 185
页数:4
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