Synthesis and in vitro antitumor activity of 1,3,4-thiadiazole derivatives based on benzisoselenazolone

被引：14

作者：

Zhao, Jie ^{[1
]}

Chen, Bao Quan ^{[1
]}

Shi, Yan Ping ^{[1
]}

Liu, Yu Ming ^{[1
]}

Zhao, Hai Chuan ^{[1
]}

Cheng, Ji ^{[1
]}

机构：

[1] Tianjin Univ Technol, Sch Chem & Chem Engn, Tianjin 300384, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2012年 / 23卷 / 07期

基金：

中国国家自然科学基金;

关键词：

1,3,4-Thiadiazole derivatives; Benzisoselenazolone; Synthesis; Antitumor activity;

D O I：

10.1016/j.cclet.2012.04.005

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of novel 1,3,4-thiadiazole derivatives based on benzisoselenazolone were synthesized and evaluated for their cytotoxicity in vitro against human liver cancer cell SSMC-7721, human breast cancer cell MCF-7 and human lung cancer cell A549 by CCK-8 assay. The results showed that compounds 7e, 7f, 7h, 7k, 7I and 7m displayed good cytotoxicity against MCF-7 cell lines. Compound 71 exhibited the most potent antitumor activities among the tested compounds. (C) 2012 Bao Quan Chen. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：817 / 819

页数：3

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