Contemporary progress in the synthesis and reactions of 2-aminobenzothiazole: a review

被引：61

作者：

Dadmal, Tulshiram L. ^{[1
,2
]}

Katre, Sangita D. ^{[3
]}

Mandewale, Mustapha C. ^{[1
]}

Kumbhare, Ravindra M. ^{[2
]}

机构：

[1] Govt Maharashtras, Ismail Yusuf Coll, Dept Chem, Bombay 400060, Maharashtra, India

[2] Indian Inst Chem Technol, Fluoroorgan Div, Hyderabad 500607, Andhra Prades, India

[3] Chhotabhai Javerbhai Patel Coll, Dept Chem, Tirora 441911, Gondia, India

来源：

NEW JOURNAL OF CHEMISTRY | 2018年 / 42卷 / 02期

关键词：

ONE-POT SYNTHESIS; COPPER-CATALYZED SYNTHESIS; METAL-FREE SYNTHESIS; OXIDATIVE C-H; BIOLOGICAL EVALUATION; UREA DERIVATIVES; DIRECT AMINATION; BENZOTHIAZOLES; INHIBITORS; EFFICIENT;

D O I：

10.1039/c7nj03776g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the past few decades, heterocyclic compounds and their derivatives have gained popularity due to their prominent medicinal importance. The versatile and synthetically accessible 2-aminobenzothiazole scaffolds are quite fascinating for multiple applications in both synthetic organic chemistry and biological fields due to their potent pharmacological activities. A large number of efforts have been made to develop a wide range of methodologies for the synthesis of 2-aminobenzothiazole and its derivatives. Moreover, 2-aminobenzothiazole significantly serves as a reactant or a reaction intermediate for affording various fused heterocycles since NH2 and endocyclic N functions of 2-aminobenzothiazole are suitable to assist reactions with common bis electrophilic reagents to form a diverse fused heterocyclic scaffold. This review highlights various synthetic methodologies and chemical reactions of 2-aminobenzothiazole.

引用

页码：776 / 797

页数：22

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