CANCER Opening LOX to metastasis

被引：12
作者：
Erez, Neta [1 ]
机构：
[1] Tel Aviv Univ, Sackler Sch Med, Dept Pathol, IL-69978 Tel Aviv, Israel
来源：
NATURE | 2015年 / 522卷 / 7554期
关键词：
PREMETASTATIC NICHE; MICROENVIRONMENT;
D O I：
10.1038/nature14529
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
New findings implicate the enzyme lysyl oxidase (LOX), secreted by oxygen-deprived breast cancer cells, in inducing bone lesions that precede and facilitate the spread of the cancer cells to the bone. See Letter p.106
引用
收藏
页码：41 / 42
页数：2
相关论文
共 12 条
[1]   The rationale for targeting the LOX family in cancer [J].
Barker, Holly E. ;
Cox, Thomas R. ;
Erler, Janine T. .
NATURE REVIEWS CANCER, 2012, 12 (08) :540-552
[2]   Denosumab in patients with cancer-a surgical strike against the osteoclast [J].
Brown, Janet E. ;
Coleman, Robert E. .
NATURE REVIEWS CLINICAL ONCOLOGY, 2012, 9 (02) :110-118
[3]   The metastatic microenvironment of breast cancer: Clinical implications [J].
Coleman, R. E. ;
Gregory, W. ;
Marshall, H. ;
Wilson, C. ;
Holen, I. .
BREAST, 2013, 22 :S50-S56
[4]   RETRACTED: The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase (Retracted Article) [J].
Cox, Thomas R. ;
Rumney, Robin M. H. ;
Schoof, Erwin M. ;
Perryman, Lara ;
Hoye, Anette M. ;
Agrawal, Ankita ;
Bird, Demelza ;
Ab Latif, Norain ;
Forrest, Hamish ;
Evans, Holly R. ;
Huggins, Iain D. ;
Lang, Georgina ;
Linding, Rune ;
Gartland, Alison ;
Erler, Janine T. .
NATURE, 2015, 522 (7554) :106-U279
[5]   Leukocytes as paracrine regulators of metastasis and determinants of organ-specific colonization [J].
Erez, Neta ;
Coussens, Lisa M. .
INTERNATIONAL JOURNAL OF CANCER, 2011, 128 (11) :2536-2544
[6]   Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche [J].
Erler, Janine T. ;
Bennewith, Kevin L. ;
Cox, Thomas R. ;
Lang, Georgina ;
Bird, Demelza ;
Koong, Albert ;
Le, Quynh-Thu ;
Giaccia, Amato J. .
CANCER CELL, 2009, 15 (01) :35-44
[7]  
Gilkes DM, 2013, FUTURE ONCOL, V9, P1623, DOI [10.2217/fon.13.92, 10.2217/FON.13.92]
[8]   Microenvironmental regulation of metastasis [J].
Joyce, Johanna A. ;
Pollard, Jeffrey W. .
NATURE REVIEWS CANCER, 2009, 9 (04) :239-252
[9]   Preparing the "Soil": The premetastatic niche [J].
Kaplan, Rosandra N. ;
Rafii, Shahin ;
Lyden, David .
CANCER RESEARCH, 2006, 66 (23) :11089-11093
[10]   The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis [J].
McAllister, Sandra S. ;
Weinberg, Robert A. .
NATURE CELL BIOLOGY, 2014, 16 (08) :717-727
12