Antibodies to Glutamate Facilitate Spatial Memory Formation in the Morris Water Maze in Aging C57BL/6 mice

被引：4

作者：

Davydova, T., V ^{[1
]}

Gruden, M. A. ^{[2
]}

Kudrin, V. S. ^{[3
]}

Narkevich, V. B. ^{[3
]}

Vetrile, L. A. ^{[1
]}

Zakharova, I. A. ^{[1
]}

Swell, R. D. E. ^{[4
]}

机构：

[1] Res Inst Gen Pathol & Pathophysiol, Moscow, Russia

[2] PK Anokhin Res Inst Normal Physiol, Moscow, Russia

[3] VV Zakusov Res Inst Pharmacol, Moscow, Russia

[4] Cardiff Univ, Sch Pharm & Pharmaceut Sci, Cardiff, Wales

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2020年 / 169卷 / 01期

关键词：

aging; memory; antibodies to glutamate; neurotransmitters;

D O I：

10.1007/s10517-020-04812-x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Intranasal administration of antibodies to glutamate in a dose of 250 mu g/kg for two weeks facilitated spatial learning and memory formation in the Morris water maze in aging C57BL/6 mice. In animals treated with glutamate antibodies, the content of serotonin and dopamine metabolites 3-MT and HVA in the hippocampus decreased, but no changes in the metabolism of neurotransmitter acids were revealed. In the prefrontal cortex, dopamine level decreased and the content of its metabolite DOPAC increased; in parallel, an increase in excitatory and inhibitory amino acids (aspartic acid, glutamate, glycine, taurine, and GABA) was observed.

引用

页码：5 / 8

页数：4

共 11 条

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Kudrin, V. S. ;

Narkevich, V. B. ;

Vetrile, L. A. ;

Zakharova, I. A. ;

Sewell, R. D. E. .

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[3]

[Грудень М.А. Gruden M.A.], 2017, [Патологическая физиология и экспериментальная терапия, Patologicheskaya fiziologiya i eksperimental'naya terapiya], V61, P13, DOI 10.25557/IGPP.2017.4.8518

[4] S100A9 Protein Aggregates Boost Hippocampal Glutamate Modifying Monoaminergic Neurochemistry: A Glutamate Antibody Sensitive Outcome on Alzheimer-like Memory Decline [J].