Enhancing the Delivery of Chemotherapeutics: Role of Biodegradable Polymeric Nanoparticles

被引：84

作者：

Ahlawat, Jyoti ^{[1
]}

Henriquez, Gabriela ^{[2
]}

Narayan, Mahesh ^{[1
]}

机构：

[1] Univ Texas El Paso, Dept Chem & Biochem, El Paso, TX 79968 USA

[2] Univ Texas El Paso, Environm Sci & Engn Dept, El Paso, TX 79968 USA

来源：

MOLECULES | 2018年 / 23卷 / 09期

关键词：

polymeric nanoparticles; mononuclear phagocyte system; drug delivery; chemotherapeutic drugs; drug toxicity; WALLED CARBON NANOTUBES; DRUG-DELIVERY; INORGANIC NANOPARTICLES; BIOMEDICAL APPLICATIONS; EXTRACELLULAR VESICLES; MULTIDRUG-RESISTANCE; TUNNELING NANOTUBES; CANCER; RELEASE; NANOTECHNOLOGY;

D O I：

10.3390/molecules23092157

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

While pharmaceutical drugs have revolutionized human life, there are several features that limit their full potential. This review draws attention to some of the obstacles currently facing the use of chemotherapeutic drugs including low solubility, poor bioavailability and high drug dose. Overcoming these issues will further enhance the applicability and potential of current drugs. An emerging technology that is geared towards improving overall therapeutic efficiency resides in drug delivery systems including the use of polymeric nanoparticles which have found widespread use in cancer therapeutics. These polymeric nanoparticles can provide targeted drug delivery, increase the circulation time in the body, reduce the therapeutic indices with minimal side-effects, and accumulate in cells without activating the mononuclear phagocyte system (MPS). Given the inroads made in the field of nanodelivery systems for pharmaceutical applications, it is of interest to review and emphasize the importance of Polymeric nanocarrier system for drug delivery in chemotherapy.

引用

页数：20

共 107 条

[1] Biocompatibility and nanostructured materials: applications in nanomedicine [J].

Adabi, Mahdi ;

Naghibzadeh, Majid ;

Adabi, Mohsen ;

Zarrinfard, Mohammad Ali ;

Esnaashari, Seyedeh Sara ;

Seifalian, Alexander M. ;

Faridi-Majidi, Reza ;

Aiyelabegan, Hammed Tanimowo ;

Ghanbari, Hossein .

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2017, 45 (04) :833-842

[2]

Albert B., 2002, MOL BIOL CELL, V4th

[3] Effect of using different types of nano materials on mechanical properties of high strength concrete [J].

Amin, Mohamed ;

Abu el-Hassan, Khaled .

CONSTRUCTION AND BUILDING MATERIALS, 2015, 80 :116-124

[4]

[Anonymous], 1978, Ann N Y Acad Sci, V308, P1

[5]

[Anonymous], 2018, Cancer facts figures

[6]

[Anonymous], J NANOMATER, DOI DOI 10.1371/J0URNAL.P0NE.0039690

[7] Bladder Cancer Incidence and Mortality: A Global Overview and Recent Trends [J].

Antoni, Sebastien ;

Ferlay, Jacques ;

Soerjomataram, Isabelle ;

Znaor, Ariana ;

Jemal, Ahmedin ;

Bray, Freddie .

EUROPEAN UROLOGY, 2017, 71 (01) :96-108

[8] Ftorafur loading and controlled release from poly(ethyl-2-cyanoacrylate) and poly(butylcyanoacrylate) nanospheres [J].

Arias, J. L. ;

Gallardo, V. ;

Ruiz, M. A. ;

Delgado, A. V. .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2007, 337 (1-2) :282-290

[9]

Austefjord Magnus Wiger, 2014, Commun Integr Biol, V7, pe27934, DOI 10.4161/cib.27934

[10] PLGA-mPEG nanoparticles of cisplatin: in vitro nanoparticle degradation, in vitro drug release and in Vivo drug residence in blood properties [J].

Avgoustakis, K ;

Beletsi, A ;

Panagi, Z ;

Klepetsanis, P ;

Karydas, AG ;

Ithakissios, DS .

JOURNAL OF CONTROLLED RELEASE, 2002, 79 (1-3) :123-135

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