The role of therapeutic plasma exchange in the catastrophic antiphospholipid syndrome

被引：45
作者：
Uthman, I
Shamseddine, A
Taher, A
机构：
[1] Amer Univ Beirut, Med Ctr, Div Hematol Oncol, Dept Internal Med, Beirut 1107 2802, Lebanon
[2] Amer Univ Beirut, Med Ctr, Div Rheumatol, Dept Internal Med, Beirut 1107 2802, Lebanon
来源：
TRANSFUSION AND APHERESIS SCIENCE | 2005年 / 33卷 / 01期
关键词：
catastrophic antiphospholipid syndrome; therapeutic plasma exchange;
D O I：
10.1016/j.transci.2004.10.025
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The catastrophic antiphospholipid syndrome (CAPS) is a life-threatening sub-entity of the antiphospholipid syndrome (APS) resulting in multiorgan failure and a mortality rate that may reach 50%. The optimal treatment regimen for CAPS is unknown. To evaluate the benefit of therapeutic plasma exchange (TPE) therapy in CAPS, we undertook a computer-assisted (MEDLINE, National Library of Medicine, Bethesda, MD) search of the literature to locate all cases of CAPS (case reports and reviews) treated with TPE. In view of the published literature so far, TPE has shown reasonable therapeutic benefits and improved survival for patients with CAPS. The use of this technique, along with anticoagulation and if needed pharmacological immunosuppression, should be considered for the acute management of patients who present with this life-threatening condition. (c) 2005 Elsevier Ltd. All rights reserved.
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页码：11 / 17
页数：7
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