A Facile Synthesis of α-Fluoro Ketones Catalyzed by [Cp*IrCl2]2

被引：25

作者：

Ahlsten, Nanna ^{[1
]}

Bartoszewicz, Agnieszka ^{[1
]}

Agrawal, Santosh ^{[1
]}

Martin-Matute, Belen ^{[1
]}

机构：

[1] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, S-10691 Stockholm, Sweden

来源：

SYNTHESIS-STUTTGART | 2011年 / 16期

基金：

瑞典研究理事会;

关键词：

iridium; fluorine; isomerization; alcohols; fluoro ketones; REDUCTIVE ALDOL REACTION; C BOND FORMATION; ALLYLIC ALCOHOLS; ENANTIOSELECTIVE SYNTHESIS; EFFICIENT SYNTHESIS; CARBONYL-COMPOUNDS; OLEFIN MIGRATION; ISOMERIZATION; FLUORINATION; CONDENSATION;

D O I：

10.1055/s-0030-1260130

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Allylic alcohols are isomerized into enolates (enols) by [Cp*IrCl2](2). The enolates react with Selectfluor present in the reaction media. This method produces alpha-fluoro ketones as single constitutional isomers in high yields.

引用

页码：2600 / 2608

页数：9

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