Mx GTPases: dynamin-like antiviral machines of innate immunity

被引：355
|
作者：
Haller, Otto [1 ]
Staeheli, Peter [1 ]
Schwemmle, Martin [1 ]
Kochs, Georg [1 ]
机构：
[1] Univ Med Ctr Freiburg, Inst Virol, Freiburg, Germany
来源：
TRENDS IN MICROBIOLOGY | 2015年 / 23卷 / 03期
关键词：
innate immunity; interferon; dynamin-like GTPase; primate evolution; influenza; HIV-1; VESICULAR STOMATITIS-VIRUS; INFLUENZA-A VIRUS; SMOOTH ENDOPLASMIC-RETICULUM; PROTEIN CONFERS RESISTANCE; MESSENGER-RNA SYNTHESIS; EXPRESSING HUMAN MXA; HEPATITIS-B-VIRUS; TRANSGENIC MICE; HIV-1; INFECTION; CONSTITUTIVE EXPRESSION;
D O I：
10.1016/j.tim.2014.12.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Mx dynamin-like GTPases are key antiviral effector proteins of the type I and type III interferon (IFN) systems. They inhibit several different viruses by blocking early steps of the viral replication cycle. We focus on new structural and functional insights and discuss recent data revealing that human MxA (MX1) provides a safeguard against introduction of avian influenza A viruses (FLUAV) into the human population. The related human MxB (MX2) serves as restriction factor for HIV-1 and other primate lentiviruses.
引用
收藏
页码：154 / 163
页数：10
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