Mx GTPases: dynamin-like antiviral machines of innate immunity

被引：366
作者：
Haller, Otto [1 ]
Staeheli, Peter [1 ]
Schwemmle, Martin [1 ]
Kochs, Georg [1 ]
机构：
[1] Univ Med Ctr Freiburg, Inst Virol, Freiburg, Germany
来源：
TRENDS IN MICROBIOLOGY | 2015年 / 23卷 / 03期
关键词：
innate immunity; interferon; dynamin-like GTPase; primate evolution; influenza; HIV-1; VESICULAR STOMATITIS-VIRUS; INFLUENZA-A VIRUS; SMOOTH ENDOPLASMIC-RETICULUM; PROTEIN CONFERS RESISTANCE; MESSENGER-RNA SYNTHESIS; EXPRESSING HUMAN MXA; HEPATITIS-B-VIRUS; TRANSGENIC MICE; HIV-1; INFECTION; CONSTITUTIVE EXPRESSION;
D O I：
10.1016/j.tim.2014.12.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Mx dynamin-like GTPases are key antiviral effector proteins of the type I and type III interferon (IFN) systems. They inhibit several different viruses by blocking early steps of the viral replication cycle. We focus on new structural and functional insights and discuss recent data revealing that human MxA (MX1) provides a safeguard against introduction of avian influenza A viruses (FLUAV) into the human population. The related human MxB (MX2) serves as restriction factor for HIV-1 and other primate lentiviruses.
引用
收藏
页码：154 / 163
页数：10
相关论文
共 107 条
[1]   The antiviral dynamin family member, MxA, tubulates lipids and localizes to the smooth endoplasmic reticulum [J].
Accola, MA ;
Huang, B ;
Al Masri, A ;
McNiven, MA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (24) :21829-21835
[2]   Human MxA protein inhibits the replication of Crimean-Congo hemorrhagic fever virus [J].
Andersson, I ;
Bladh, L ;
Mousavi-Jazi, M ;
Magnusson, KE ;
Lundkvist, Å ;
Haller, O ;
Mirazimi, A .
JOURNAL OF VIROLOGY, 2004, 78 (08) :4323-4329
[3]   ANTIVIRAL STATE AGAINST INFLUENZA-VIRUS NEUTRALIZED BY MICROINJECTION OF ANTIBODIES TO INTERFERON-INDUCED MX PROTEINS [J].
ARNHEITER, H ;
HALLER, O .
EMBO JOURNAL, 1988, 7 (05) :1315-1320
[4]   TRANSGENIC MICE WITH INTRACELLULAR IMMUNITY TO INFLUENZA-VIRUS [J].
ARNHEITER, H ;
SKUNTZ, S ;
NOTEBORN, M ;
CHANG, S ;
MEIER, E .
CELL, 1990, 62 (01) :51-61
[5]   Mouse Mx2 gene:: organization, mRNA expression and the role of the interferon-response promoter in its regulation [J].
Asano, A ;
Jin, HK ;
Watanabe, T .
GENE, 2003, 306 :105-113
[6]   Inhibition of Dugbe nairovirus replication by human MxA protein [J].
Bridgen, A ;
Dalrymple, DA ;
Weber, F ;
Elliott, RM .
VIRUS RESEARCH, 2004, 99 (01) :47-50
[7]   PARENTAL INFLUENZA VIRION NUCLEOCAPSIDS ARE EFFICIENTLY TRANSPORTED INTO THE NUCLEI OF MURINE CELLS EXPRESSING THE NUCLEAR INTERFERON-INDUCED MX PROTEIN [J].
BRONI, B ;
JULKUNEN, I ;
CONDRA, JH ;
DAVIES, ME ;
BERRY, MJ ;
KRUG, RM .
JOURNAL OF VIROLOGY, 1990, 64 (12) :6335-6340
[8]   Host and Viral Determinants of Mx2 Antiretroviral Activity [J].
Busnadiego, Idoia ;
Kane, Melissa ;
Rihn, Suzannah J. ;
Preugschas, Hannah F. ;
Hughes, Joseph ;
Blanco-Melo, Daniel ;
Strouvelle, Victoria P. ;
Zang, Trinity M. ;
Willett, Brian J. ;
Boutell, Chris ;
Bieniasz, Paul D. ;
Wilson, Sam J. .
JOURNAL OF VIROLOGY, 2014, 88 (14) :7738-7752
[9]   An Intramolecular Signaling Element that Modulates Dynamin Function In Vitro and In Vivo [J].
Chappie, Joshua S. ;
Acharya, Sharmistha ;
Liu, Ya-Wen ;
Leonard, Marilyn ;
Pucadyil, Thomas J. ;
Schmid, Sandra L. .
MOLECULAR BIOLOGY OF THE CELL, 2009, 20 (15) :3561-3571
[10]  
ChelbiAlix MK, 1995, LEUKEMIA, V9, P2027
12345678910