The association between a biomarker score for fruit and vegetable intake and incident type 2 diabetes: the EPIC-Norfolk study

被引：41

作者：

Cooper, A. J. M. ^{[1
]}

Sharp, S. J. ^{[1
]}

Luben, R. N. ^{[2
]}

Khaw, K-T ^{[3
]}

Wareham, N. J. ^{[1
]}

Forouhi, N. G. ^{[1
]}

机构：

[1] Univ Cambridge, Sch Clin Med, Addenbrookes Hosp, MRC Epidemiol Unit,Inst Metab Sci, Cambridge CB2 0QQ, England

[2] Univ Cambridge, MRC Ctr Nutr Epidemiol Canc Prevent & Survival, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Cambridge, England

[3] Univ Cambridge, Sch Clin Med, Clin Gerontol Unit, Cambridge, England

来源：

EUROPEAN JOURNAL OF CLINICAL NUTRITION | 2015年 / 69卷 / 04期

基金：

英国医学研究理事会;

关键词：

RANDOMIZED CONTROLLED-TRIAL; BETA-CAROTENE SUPPLEMENTATION; PLASMA CAROTENOIDS; ALPHA-TOCOPHEROL; DIETARY-INTAKE; VITAMIN-C; US ADULTS; RISK; CANCER; CONSUMPTION;

D O I：

10.1038/ejcn.2014.246

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

BACKGROUND/OBJECTIVES: Biomarkers for a mixed fruit and vegetable (FV) diet are needed to provide a better understanding of the association between FV intake and type 2 diabetes. We aimed to examine the prospective association between a composite score comprised of three biomarkers of FV intake in free-living populations and incident diabetes. SUBJECTS/METHODS: A total of 318 incident diabetes cases and 926 controls from the EPIC (European Prospective Investigation of Cancer)-Norfolk study aged 40-79 years at baseline (1993-1997), completed 7-day prospective food diary and had plasma vitamin C and carotenoid measures. A composite biomarker score (CB-score) comprising the sum of plasma vitamin C, beta-carotene and lutein was derived. Odds ratios (ORs) and 95% confidence intervals (CIs) for incident diabetes were estimated using multivariable logistic regression. RESULTS: A strong inverse association was found between the CB-score and incident diabetes. The ORs (95% CI) of diabetes comparing quartiles Q2, Q3 and Q4 of the CB-score with Q1 (reference category) were 0.70 (0.49, 1.00), 0.34 (0.23, 0.52) and 0.19 (0.12, 0.32), respectively, and 0.49 (0.40, 0.58) per s.d. change in CB-score in a model adjusted for demographic and lifestyle factors. The association was marginally attenuated after additionally adjusting for body mass index and waist circumference (0.60 (0.49 and 0.74) per s.d. change in CB-score). CONCLUSIONS: A combination of biomarkers representing the intake of a mixed FV diet was strongly inversely associated with incident diabetes. These findings provide further support for measuring dietary biomarkers in studies of diet-disease associations and highlight the importance of consuming FV for the prevention of diabetes.

引用

页码：449 / 454

页数：6

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