Increased Serum Zonulin Levels as an Intestinal Permeability Marker in Autistic Subjects

被引:99
作者
Esnafoglu, Erman [1 ]
Cirrik, Selma [2 ]
Ayyildiz, Sema Nur [3 ]
Erdil, Abdullah [4 ]
Erturk, Emine Yurdakul [4 ]
Dagli, Abdullah [4 ]
Noyan, Tevfik [3 ]
机构
[1] Ordu Univ, Res & Training Hosp, Dept Child & Adolescent Psychiat, Fac Med, TR-52200 Ordu, Turkey
[2] Ordu Univ, Dept Med Physiol, Fac Med, Ordu, Turkey
[3] Ordu Univ, Res & Training Hosp, Dept Biochem, Fac Med, Ordu, Turkey
[4] Ordu Univ, Res & Training Hosp, Dept Pediatry, Fac Med,Dept Pediat, Ordu, Turkey
关键词
CELIAC-DISEASE; GASTROINTESTINAL SYMPTOMS; SPECTRUM DISORDERS; LARAZOTIDE ACETATE; CHILDREN; GLUTEN; BARRIER; PATHOPHYSIOLOGY; PROTEINS; BLIND;
D O I
10.1016/j.jpeds.2017.04.004
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective To evaluate the serum levels of zonulin, which regulates tight junctions between enterocytes and is a physiological modulator controlling intestinal permeability, in patients with autism spectrum disorders (ASDs). Study design Serum zonulin levels were determined in 32 patients with ASD and 33 healthy controls using an enzyme-linked immunosorbent assay. The severity of ASD symptoms was assessed with the Childhood Autism Rating Scale. Results Serum zonulin levels were significantly higher in the patients with ASD (122.3 +/- 98.46 ng/mL) compared with the healthy controls (41.89 +/- 45.83 ng/mL). There was a positive correlation between zonulin levels and Childhood Autism Rating Scale score when all subjects were assessed (r = 0.523; P <.001). Conclusions This study suggests that zonulin, which regulates intestinal permeability, plays a role in the development of symptoms of ASD.
引用
收藏
页码:240 / 244
页数:5
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