Recent Trends in Survival of Patients With Pancreatic Cancer in Germany and the United States

被引:3
作者
Sirri, Eunice [1 ]
Castro, Felipe Andres [2 ]
Kieschke, Joachim [1 ]
Jansen, Lina [2 ]
Emrich, Katharina [3 ]
Gondos, Adam [2 ]
Holleczek, Bernd [4 ]
Katalinic, Alexander [5 ]
Urbschat, Iris [1 ]
Vohmann, Claudia [1 ]
Brenner, Hermann [2 ,6 ,7 ,8 ]
机构
[1] Lower Saxony Canc Registry, Oldenburg, Germany
[2] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Neuenheimer Feld 581, D-69120 Heidelberg, Germany
[3] Johannes Gutenberg Univ Mainz, Canc Registry Rhineland Palatinate, Inst Med Biostat Epidemiol & Informat, Univ Ctr, D-55122 Mainz, Germany
[4] Saarland Canc Registry, Saarbrucken, Germany
[5] Canc Registry Schleswig Holstein, Lubeck, Germany
[6] German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany
[7] Natl Ctr Tumor Dis NCT, Heidelberg, Germany
[8] German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany
关键词
pancreatic ductal adenocarcinoma; period analysis; relative survival; UP-TO-DATE; PERIOD ANALYSIS; EMPIRICAL-EVALUATION; HOSPITAL VOLUME; OLDER PATIENTS; POPULATION; SURGERY; ADENOCARCINOMA; RESECTION; RISK;
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Objectives: Survival improvement for pancreatic cancer has not been observed in the last 4 decades. We report the most up-to-date population-based relative survival (RS) estimates and recent trends in Germany and the United States. Methods: Data for patients diagnosed in 1997 to 2010 and followed up to 2010 were drawn from 12 population-based German cancer registries and the US SEER (Surveillance, Epidemiology and End Results) 13 registries database. Using period analysis, 5-year RS for 2007 to 2010 was derived. Model-based period analysis was used to assess 5-year RS time trends, 2002-2010. Results: In total 28,977 (Germany) and 34,793 (United States) patients aged 15 to 74 years were analyzed. Five-year RS was 10.7% and 10.3% in Germany and the United States, respectively, and strongly decreased with age and tumor spread. Prognosis slightly improved from the period 2002-2004 to 2008-2010 (overall age-adjusted RS: +2.5% units in Germany and +3.4% units in the United States); improvement was particularly strong for regional stage and head and body subsites in Germany and for localized and regional stages and tail subsite in the United States. Conclusions: Although pancreatic cancer survival continues to be poor for advanced-stage patients, our study disclosed encouraging indications of first improvements in 5-year RS after decades of stagnation.
引用
收藏
页码:908 / 914
页数:7
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