Exosomes: Potential Disease Biomarkers and New Therapeutic Targets

被引：102

作者：

Mosquera-Heredia, Maria, I ^{[1
]}

Morales, Luis C. ^{[1
]}

Vidal, Oscar M. ^{[1
]}

Barcelo, Ernesto ^{[2
]}

Silvera-Redondo, Carlos ^{[1
]}

Velez, Jorge, I ^{[3
]}

Garavito-Galofre, Pilar ^{[1
]}

机构：

[1] Univ Norte, Dept Med, Barranquilla 081007, Colombia

[2] Inst Colombiano Neuropedag, Barranquilla 080020, Colombia

[3] Univ Norte, Dept Ind Engn, Barranquilla 081007, Colombia

来源：

BIOMEDICINES | 2021年 / 9卷 / 08期

关键词：

exosome; biogenesis; intercellular communication; biomarker; therapeutic vehicle; MESENCHYMAL STROMAL CELLS; C-TERMINAL FRAGMENTS; EXTRACELLULAR VESICLES; ALZHEIMERS-DISEASE; DENDRITIC CELLS; MEDIATED ENDOCYTOSIS; PLACENTAL EXOSOMES; PLASMA-MEMBRANE; TUMOR-GROWTH; IN-VITRO;

D O I：

10.3390/biomedicines9081061

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Exosomes are extracellular vesicles released by cells, both constitutively and after cell activation, and are present in different types of biological fluid. Exosomes are involved in the pathogenesis of diseases, such as cancer, neurodegenerative diseases, pregnancy disorders and cardiovascular diseases, and have emerged as potential non-invasive biomarkers for the detection, prognosis and therapeutics of a myriad of diseases. In this review, we describe recent advances related to the regulatory mechanisms of exosome biogenesis, release and molecular composition, as well as their role in health and disease, and their potential use as disease biomarkers and therapeutic targets. In addition, the advantages and disadvantages of their main isolation methods, characterization and cargo analysis, as well as the experimental methods used for exosome-mediated drug delivery, are discussed. Finally, we present potential perspectives for the use of exosomes in future clinical practice.

引用

页数：48

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