Detection of tumor spread through airspaces by airway secretion cytology from resected lung cancer specimens

被引：26

作者：

Isaka, Tetsuya ^{[1
,2
]}

Yokose, Tomoyuki ^{[3
]}

Miyagi, Yohei ^{[4
]}

Washimi, Kota ^{[3
]}

Nishii, Teppei ^{[1
]}

Ito, Hiroyuki ^{[1
]}

Nakayama, Haruhiko ^{[1
]}

Yamada, Kouzo ^{[5
]}

Masuda, Munetaka ^{[2
]}

机构：

[1] Kanagawa Canc Ctr, Dept Thorac Surg, Asahi Ku, 2-3-2 Nakao, Yokohama, Kanagawa 2418515, Japan

[2] Yokohama City Univ, Dept Surg, 3-9 Fukuura, Yokohama, Kanagawa 2360004, Japan

[3] Kanagawa Canc Ctr, Dept Pathol, Asahi Ku, 2-3-2 Nakao, Yokohama, Kanagawa 2418515, Japan

[4] Kanagawa Canc Ctr, Mol Pathol & Genet Div, Res Inst, Asahi Ku, 2-3-2 Nakao, Yokohama, Kanagawa 2418515, Japan

[5] Kanagawa Canc Ctr, Dept Thorac Oncol, Asahi Ku, 2-3-2 Nakao, Yokohama, Kanagawa 2418515, Japan

来源：

PATHOLOGY INTERNATIONAL | 2017年 / 67卷 / 10期

关键词：

adenocarcinoma; cytology; EGFR; exon 19 deletion mutation; exon 21 L858R mutation; lung cancer; micropapillary; STAS; GROWTH-FACTOR RECEPTOR; SIGNIFICANTLY POOR-PROGNOSIS; DISTINCT PATHOLOGICAL MARKER; PULMONARY ADENOCARCINOMA; MICROPAPILLARY PATTERN; LIMITED RESECTION; CUT-END; IMPACT; CLASSIFICATION; RECURRENCE;

D O I：

10.1111/pin.12570

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

It currently remains unclear whether tumor spread through airspaces (STAS) actually exist in vivo or are an artifact. The morphologies of STAS and tumor cell clusters in airway secretions collected from the segmental or lobar bronchus of resected lung adenocarcinomas and squamous cell carcinomas were compared among 48 patients. The EGFR status of tumor cell clusters in airway secretions was also compared with that of the main tumor in EGFR mutant adenocarcinomas. Tumor cell clusters were observed in the airway secretion cytology of ten patients (20.8%), and eight patients were adenocarcinoma (20.0% of adenocarcinoma). The morphology of STAS closely resembled that of tumor cell clusters detected in airway secretion cytology. The positive rates of airway secretion cytology were 83.3%, 100%, and 50% in papillary adenocarcinoma, micropapillary adenocarcinoma, and invasive mucinous adenocarcinoma, respectively. Among three EGFR mutant adenocarcinomas, the EGFR mutation subtypes of the main tumors in FFPE sections and tumor cell clusters in airway secretions were identical. These indicate that STAS may be detected in the airway secretion cytology. STAS is common in papillary or micropapillary adenocarcinoma and may spread as far as the segmental or lobar bronchus at the time of surgery.

引用

页码：487 / 494

页数：8

共 29 条

[1] Micropapillary component in lung adenocarcinoma -: A distinctive histologic feature with possible prognostic significance [J].