Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil

被引：11

作者：

Polotto, Milena ^{[1
,2
]}

Casella, Tiago ^{[2
]}

Tolentino, Fernanda Modesto ^{[1
,2
]}

Mataruco, Mayra Mioto ^{[3
]}

Madela Porto, Naiady Konno ^{[2
]}

Batista Binhardi, Mirella Fontana ^{[1
]}

Lelles Nogueira, Mara Correa ^{[2
]}

机构：

[1] Ctr Lab Reg Sao Jose do Rio Preto, Inst Adolfo Lutz, Sao Jose Do Rio Preto, SP, Brazil

[2] Fac Med Sao Jose do Rio Preto, Ctr Invest Microrganismos, Sao Jose Do Rio Preto, SP, Brazil

[3] Univ Fed Sao Carlos, Sao Carlos, SP, Brazil

来源：

REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL | 2020年 / 53卷

关键词：

Acinetobacter baumannii; Carbapenemases; Aminoglycoside modifying enzymes; TREATMENT OPTIONS; RESISTANT; IDENTIFICATION; MECHANISMS;

D O I：

10.1590/0037-8682-0094-2019

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Introduction: Acinetobacter baumannii are opportunistic bacteria. highly capable of acquiring antimicrobial resistance through the production of carbapenemases and aminoglycoside modifying enzymes (AMEs). Methods: Carbapenemase and AME genes were investigated in A. baumannii recovered from inpatients of a Brazilian hospital. Results: The key genes found were bla(OXA-51-like) the association ISAba1- bla(OXA-23-like), and the AME genes aph(3')-VI, aac(6')-Ib, aac(3)-Ia, and aph(3')-Ia. Different clusters , spread through the institution wards. Conclusions: The dissemination of bla(OXA-23-like) and AME-carrying A. baumannii through the hospital highlights the need for improved preventive measures to reduce the spread of infection.

引用

页数：4

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