Targeting transcription factor STAT3 for cancer prevention and therapy

被引：233

作者：

Chai, Edna Zhi Pei ^{[1
]}

Shanmugam, Muthu K. ^{[1
]}

Arfuso, Frank ^{[2
]}

Dharmarajan, Arunasalam ^{[2
]}

Wang, Chao ^{[1
,3
]}

Kumar, Alan Prem ^{[1
,2
,3
,4
]}

Samy, Ramar Perumal ^{[5
]}

Lim, Lina H. K. ^{[5
]}

Wang, Lingzhi ^{[1
,3
]}

Goh, Boon Cher ^{[1
,3
,6
]}

Ahn, Kwang Seok ^{[7
]}

Hui, Kam Man ^{[8
]}

Sethi, Gautam ^{[1
,2
]}

机构：

[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore 117600, Singapore

[2] Curtin Univ, CHIRI Biosci Res Precinct, Sch Biomed Sci, Perth, WA 6009, Australia

[3] Canc Sci Inst Singapore, Ctr Translat Med, 14 Med Dr,11-01M, Singapore 117599, Singapore

[4] Univ N Texas, Dept Biol Sci, Denton, TX 76203 USA

[5] Natl Univ Singapore, Yong Loo Lin Sch Med, NUHS, Dept Physiol,Ctr Life Sci, Singapore 117456, Singapore

[6] Natl Univ Hlth Syst, Dept Haematol Oncol, Singapore 117597, Singapore

[7] Kyung Hee Univ, Coll Korean Med, Seoul 130701, South Korea

[8] Natl Canc Ctr, Humphrey Oei Inst Canc Res, Div Cellular & Mol Res, Singapore 169610, Singapore

来源：

PHARMACOLOGY & THERAPEUTICS | 2016年 / 162卷

基金：

英国医学研究理事会; 新加坡国家研究基金会;

关键词：

STAT3; Cancer; Cytokines; Proliferation; Apoptosis; Angiogenesis; NF-KAPPA-B; HUMAN HEPATOCELLULAR-CARCINOMA; HUMAN MULTIPLE-MYELOMA; RESVERATROL-INDUCED APOPTOSIS; PROMISING ANTICANCER DRUG; GROWTH-FACTOR RECEPTOR; DNA-BINDING ACTIVITY; CELL LUNG-CANCER; SIGNAL TRANSDUCER; IN-VITRO;

D O I：

10.1016/j.pharmthera.2015.10.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Signal Transducers and Activators of Transcription (STATs) comprise an important class of transcription factors that have been implicated in a wide variety of essential cellular functions related to proliferation, survival, and angiogenesis. Among various STAT members, STAT3 is frequently overexpressed in tumor cells as well as tissue samples, and regulates the expression of numerous oncogenic genes controlling the growth and metastasis of tumor cells. The current review briefly discusses the importance of STAT3 as a potential target for cancer therapy and also provides novel insights into various classes of existing pharmacological inhibitors of this transcription factor that can be potentially developed as anti-cancer drugs. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：86 / 97

页数：12

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