Prognostic and predictive biomarkers in melanoma: an update

被引：20
作者：
Foth, Mona [1 ,2 ,3 ]
Wouters, Jasper [1 ,2 ,4 ]
de Chaumont, Ciaran [1 ,2 ,5 ]
Dynoodt, Peter [1 ,2 ]
Gallagher, William M. [1 ,2 ,6 ]
机构：
[1] OncoMark Ltd, NovaUCD, Bellfield, Ireland
[2] Univ Coll Dublin, Dublin 2, Ireland
[3] Beatson Inst, Canc Res UK, Glasgow, Lanark, Scotland
[4] Katholieke Univ Leuven, Dept Imaging & Pathol, Translat Cell & Tissue Res, Leuven, Belgium
[5] Royal Coll Surgeons Ireland, Dept Physiol & Med Phys, Dublin 2, Ireland
[6] Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Sch Biomol & Biomed Sci, UCD Canc Biol & Therapeut Lab, Dublin 2, Ireland
来源：
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2016年 / 16卷 / 02期
关键词：
Melanoma; biomarker; prognostic; predictive; multi-marker assay; CIRCULATING TUMOR-CELLS; RECOMBINANT INTERLEUKIN-2 THERAPY; GENE-EXPRESSION SIGNATURES; COPY NUMBER GAINS; METASTATIC MELANOMA; BRAF MUTATIONS; CUTANEOUS MELANOMA; ANTI-PD-L1; ANTIBODY; MALIGNANT-MELANOMA; PROTEIN EXPRESSION;
D O I：
10.1586/14737159.2016.1126511
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Malignant melanoma is one of the most aggressive cancers. Several new therapeutic strategies that focus on immuno- and/or targeted therapy have been developed, which have entered clinical trials or already been approved. This review provides an update on prognostic and predictive biomarkers in melanoma that may be used to improve the clinical management of patients. Prognostic markers include conventional histopathological characteristics, chromosomal aberrations, gene expression patterns and miRNA profiles. There is a trend towards multi-marker assays and whole-genome molecular screening methods to determine the prognosis of individual patients. Predictive biomarkers, including targeted components of signal transduction, developmental or transcriptional pathways, can be used to determine patient response towards a particular treatment or combination thereof. The rapid evolution of sequencing technologies and multi-marker screening will change the spectrum of patients who become candidates for therapeutic agents, and in addition create new ethical and regulatory challenges.
引用
收藏
页码：223 / 237
页数：15
相关论文
共 116 条
  • [11] Molecular classification of cutaneous malignant melanoma by gene expression profiling
    Bittner, M
    Meitzer, P
    Chen, Y
    Jiang, Y
    Seftor, E
    Hendrix, M
    Radmacher, M
    Simon, R
    Yakhini, Z
    Ben-Dor, A
    Sampas, N
    Dougherty, E
    Wang, E
    Marincola, F
    Gooden, C
    Lueders, J
    Glatfelter, A
    Pollock, P
    Carpten, J
    Gillanders, E
    Leja, D
    Dietrich, K
    Beaudry, C
    Berens, M
    Alberts, D
    Sondak, V
    Hayward, N
    Trent, J
    [J]. NATURE, 2000, 406 (6795) : 536 - 540
  • [12] Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival
    Bogunovic, Dusan
    O'Neill, David W.
    Belitskaya-Levy, Ilana
    Vacic, Vladimir
    Yu, Yi-Lo
    Adams, Sylvia
    Darvishian, Farbod
    Berman, Russell
    Shapiro, Richard
    Pavlick, Anna C.
    Lonardi, Stefano
    Zavadil, Jiri
    Osman, Iman
    Bhardwaj, Nina
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (48) : 20429 - 20434
  • [13] Safety and Activity of Anti-PD-L1 Antibody in Patients with Advanced Cancer
    Brahmer, Julie R.
    Tykodi, Scott S.
    Chow, Laura Q. M.
    Hwu, Wen-Jen
    Topalian, Suzanne L.
    Hwu, Patrick
    Drake, Charles G.
    Camacho, Luis H.
    Kauh, John
    Odunsi, Kunle
    Pitot, Henry C.
    Hamid, Omid
    Bhatia, Shailender
    Martins, Renato
    Eaton, Keith
    Chen, Shuming
    Salay, Theresa M.
    Alaparthy, Suresh
    Grosso, Joseph F.
    Korman, Alan J.
    Parker, Susan M.
    Agrawal, Shruti
    Goldberg, Stacie M.
    Pardoll, Drew M.
    Gupta, Ashok
    Wigginton, Jon M.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (26) : 2455 - 2465
  • [14] mRNA-transfected Dendritic Cells Expressing Polypeptides That Link MHC-I Presentation to Constitutive TLR4 Activation Confer Tumor Immunity
    Cafri, Gal
    Sharbi-Yunger, Adi
    Tzehoval, Esther
    Alteber, Zoya
    Gross, Tamar
    Vadai, Ezra
    Margalit, Alon
    Gross, Gideon
    Eisenbach, Lea
    [J]. MOLECULAR THERAPY, 2015, 23 (08) : 1391 - 1400
  • [15] Automated subcellular localization and quantification of protein expression in tissue microarrays
    Camp, RL
    Chung, GG
    Rimm, DL
    [J]. NATURE MEDICINE, 2002, 8 (11) : 1323 - 1327
  • [16] MicroRNA Expression Profiles Associated with Mutational Status and Survival in Malignant Melanoma
    Caramuta, Stefano
    Egyhazi, Suzanne
    Rodolfo, Monica
    Witten, Daniela
    Hansson, Johan
    Larsson, Catharina
    Lui, Weng-Onn
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2010, 130 (08) : 2062 - 2070
  • [17] Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
    Chapman, Paul B.
    Hauschild, Axel
    Robert, Caroline
    Haanen, John B.
    Ascierto, Paolo
    Larkin, James
    Dummer, Reinhard
    Garbe, Claus
    Testori, Alessandro
    Maio, Michele
    Hogg, David
    Lorigan, Paul
    Lebbe, Celeste
    Jouary, Thomas
    Schadendorf, Dirk
    Ribas, Antoni
    O'Day, Steven J.
    Sosman, Jeffrey A.
    Kirkwood, John M.
    Eggermont, Alexander M. M.
    Dreno, Brigitte
    Nolop, Keith
    Li, Jiang
    Nelson, Betty
    Hou, Jeannie
    Lee, Richard J.
    Flaherty, Keith T.
    McArthur, Grant A.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (26) : 2507 - 2516
  • [18] Stage-specific prognostic biomarkers in melanoma
    Cheng, Yabin
    Lu, Jing
    Chen, Guangdi
    Ardekani, Gholamreza Safaee
    Rotte, Anand
    Martinka, Magdalena
    Xu, Xuezhu
    McElwee, Kevin J.
    Zhang, Guohong
    Zhou, Youwen
    [J]. ONCOTARGET, 2015, 6 (06) : 4180 - 4189
  • [19] First FDA Authorization for Next-Generation Sequencer
    Collins, Francis S.
    Hamburg, Margaret A.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (25) : 2369 - 2371
  • [20] Mutations of the BRAF gene in human cancer
    Davies, H
    Bignell, GR
    Cox, C
    Stephens, P
    Edkins, S
    Clegg, S
    Teague, J
    Woffendin, H
    Garnett, MJ
    Bottomley, W
    Davis, N
    Dicks, N
    Ewing, R
    Floyd, Y
    Gray, K
    Hall, S
    Hawes, R
    Hughes, J
    Kosmidou, V
    Menzies, A
    Mould, C
    Parker, A
    Stevens, C
    Watt, S
    Hooper, S
    Wilson, R
    Jayatilake, H
    Gusterson, BA
    Cooper, C
    Shipley, J
    Hargrave, D
    Pritchard-Jones, K
    Maitland, N
    Chenevix-Trench, G
    Riggins, GJ
    Bigner, DD
    Palmieri, G
    Cossu, A
    Flanagan, A
    Nicholson, A
    Ho, JWC
    Leung, SY
    Yuen, ST
    Weber, BL
    Siegler, HF
    Darrow, TL
    Paterson, H
    Marais, R
    Marshall, CJ
    Wooster, R
    [J]. NATURE, 2002, 417 (6892) : 949 - 954
12345678910