Four new 6-Nor-5(6→7)abeo-abietane type diterpenes and antitumoral cytotoxic diterpene constituents from the bark of Taiwania cryptomerioides

被引：84

作者：

Chang, CI

Chang, JY

Kuo, CC ^{[1
]}

Pan, WY

Kuo, YH

机构：

[1] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan

[2] Natl Pingtung Univ Sci & Technol, Grad Inst Biotechnol, Pingtung, Taiwan

[3] Natl Hlth Res Inst, Div Canc Res, Taipei, Taiwan

来源：

PLANTA MEDICA | 2005年 / 71卷 / 01期

关键词：

Taiwania cryptomerioides; Taxodiaceae; diterpenes; 6-nor-5(6 -> 7)abeo-abietane; cytotoxic activity;

D O I：

10.1055/s-2005-837754

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new 6-nor-5(6-->7)abeo-abietane type diterpenes designated as taiwaniaquinone G, taiwaniaquinone H, taiwamaquinol E and taiwamaquinol F and eight known diterpenes, taiwamaquinones A (5), D (6), E, F (8), and taiwaniaquinols A (9), B, C (11), D (12) were isolated from the bark of Taiwania cryptomerioides. Their Structures were elucidated on the basis of spectroscopic studies. These twelve diterpenes were evaluated for in vitro anti-tumoral cytotoxic activity. The result demonstrated that compounds 5, 6, 8, 9, 11, and 12 bearing an aldehyde group possessed potent cytotoxic activity against KB epidermoid carcinoma cancer cell lines with IC50 values of 6.9, 7.2, 4.4, 8.3, 8.1, and 3.5 muM, respectively.

引用

页码：72 / 76

页数：5

共 23 条

[1] A cytotoxic lobane diterpene from the formosan soft coral Sinularia inelegans [J].