Isolation of Angola-like Marburg virus from Egyptian rousette bats from West Africa

被引：72

作者：

Amman, Brian R. ^{[1
]}

Bird, Brian H. ^{[2
]}

Bakarr, Ibrahim A. ^{[3
]}

Bangura, James ^{[2
,4
]}

Schuh, Amy J. ^{[1
]}

Johnny, Jonathan ^{[3
]}

Sealy, Tara K. ^{[1
]}

Conteh, Immah ^{[3
]}

Koroma, Alusine H. ^{[3
]}

Foday, Ibrahim ^{[3
]}

Amara, Emmanuel ^{[4
]}

Bangura, Abdulai A. ^{[4
]}

Gbakima, Aiah A. ^{[5
]}

Tremeau-Bravard, Alexandre ^{[3
]}

Belaganahalli, Manjunatha ^{[3
]}

Dhanota, Jasjeet ^{[2
]}

Chow, Andrew ^{[2
]}

Ontiveros, Victoria ^{[2
]}

Gibson, Alexandra ^{[2
]}

Turay, Joseph ^{[4
]}

Patel, Ketan ^{[1
]}

Graziano, James ^{[1
]}

Bangura, Camilla ^{[3
]}

Kamanda, Emmanuel S. ^{[3
]}

Osborne, Augustus ^{[3
]}

Saidu, Emmanuel ^{[3
]}

Musa, Jonathan ^{[3
]}

Bangura, Doris ^{[3
]}

Williams, Samuel Maxwell Tom ^{[3
]}

Wadsworth, Richard ^{[3
]}

Turay, Mohamed ^{[4
]}

Edwin, Lavalie ^{[4
]}

Mereweather-Thompson, Vanessa ^{[4
]}

Kargbo, Dickson ^{[4
]}

Bairoh, Fatmata V. ^{[4
]}

Kanu, Marilyn ^{[4
]}

Robert, Willie ^{[4
]}

Lungai, Victor ^{[4
]}

Wadoum, Raoul Emeric Guetiya ^{[4
]}

Coomber, Moinya ^{[4
]}

Kanu, Osman ^{[4
]}

Jambai, Amara ^{[6
]}

Kamara, Sorie M. ^{[7
]}

Taboy, Celine H. ^{[1
]}

Singh, Tushar ^{[8
]}

Mazet, Jonna A. K. ^{[2
]}

Nichol, Stuart T. ^{[1
]}

Goldstein, Tracey ^{[2
]}

Towner, Jonathan S. ^{[1
]}

Lebbie, Aiah ^{[3
]}

机构：

[1] Ctr Dis Control & Prevent, Viral Special Pathogens Branch, 1600 Clifton Rd NE, Atlanta, GA 30329 USA

[2] Univ Calif Davis, Hlth Inst 1, Sch Vet Med, 1089 Vet Med Dr,VetMed 3B,Ground Floor West, Davis, CA 95616 USA

[3] Njala Univ, Dept Biol Sci, Njala, Sierra Leone

[4] Univ Makeni, Makeni, Sierra Leone

[5] Minist Tech & Higher Educ, Freetown, Sierra Leone

[6] Minist Hlth & Sanitat, Brookfields, Freetown, Sierra Leone

[7] Minist Agr & Forestry, Brookfields, Freetown, Sierra Leone

[8] Ctr Dis Control & Prevent, Ctr Global Hlth, Freetown, Sierra Leone

来源：

NATURE COMMUNICATIONS | 2020年 / 11卷 / 01期

关键词：

EBOLA HEMORRHAGIC-FEVER; OUTBREAK; CONGO; IDENTIFICATION; INFECTION; ANIMALS; DISEASE; IMPACT; UGANDA;

D O I：

10.1038/s41467-020-14327-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Marburg virus (MARV) causes sporadic outbreaks of severe Marburg virus disease (MVD). Most MVD outbreaks originated in East Africa and field studies in East Africa, South Africa, Zambia, and Gabon identified the Egyptian rousette bat (ERB; Rousettus aegyptiacus) as a natural reservoir. However, the largest recorded MVD outbreak with the highest case-fatality ratio happened in 2005 in Angola, where direct spillover from bats was not shown. Here, collaborative studies by the Centers for Disease Control and Prevention, Njala University, University of California, Davis USAID-PREDICT, and the University of Makeni identify MARV circulating in ERBs in Sierra Leone. PCR, antibody and virus isolation data from 1755 bats of 42 species shows active MARV infection in approximately 2.5% of ERBs. Phylogenetic analysis identifies MARVs that are similar to the Angola strain. These results provide evidence of MARV circulation in West Africa and demonstrate the value of pathogen surveillance to identify previously undetected threats.

引用

页数：9

共 51 条

[1] Outbreak of Marburg Hemorrhagic Fever Among Miners in Kamwenge and Ibanda Districts, Uganda, 2007
Adjemian, Jennifer
Farnon, Eileen C.
Tschioko, Florimond
Wamala, Joseph F.
Byaruhanga, Emmanuel
Bwire, Godfrey S.
Kansiime, Edgar
Kagirita, Atek
Ahimbisibwe, Sam
Katunguka, F.
Jeffs, Ben
Lutwama, Julius J.
Downing, Robert
Tappero, Jordan W.
Formenty, Pierre
Amman, Brian
Manning, Craig
Towner, Jonathan
Nichol, Stuart T.
Rollin, Pierre E.
[J]. JOURNAL OF INFECTIOUS DISEASES, 2011, 204 : S796 - S799
[2] Genomic analysis of filoviruses associated with four viral hemorrhagic fever outbreaks in Uganda and the Democratic Republic of the Congo in 2012
Albarino, C. G.
Shoemaker, T.
Khristova, M. L.
Wamala, J. F.
Muyembe, J. J.
Balinandi, S.
Tumusiime, A.
Campbell, S.
Cannon, D.
Gibbons, A.
Bergeron, E.
Bird, B.
Dodd, K.
Spiropoulou, C.
Erickson, B. R.
Guerrero, L.
Knust, B.
Nichol, S. T.
Rollin, P. E.
Stroeher, U.
[J]. VIROLOGY, 2013, 442 (02) : 97 - 100
[3] Amman B. R., 2017, EBOLAVIRUSES METHODS, V30, P373
[4] Ecology of Filoviruses
Amman, Brian R.
Swanepoel, Robert
Nichol, Stuart T.
Towner, Jonathan S.
[J]. MARBURG- AND EBOLAVIRUSES: FROM ECOSYSTEMS TO MOLECULES, 2017, 411 : 23 - 61
[5] ORAL SHEDDING OF MARBURG VIRUS IN EXPERIMENTALLY INFECTED EGYPTIAN FRUIT BATS (ROUSETTUS AEGYPTIACUS)
Amman, Brian R.
Jones, Megan E. B.
Sealy, Tara K.
Uebelhoer, Luke S.
Schuh, Amy J.
Bird, Brian H.
Coleman-McCray, JoAnn D.
Martin, Brock E.
Nichol, Stuart T.
Towner, Jonathan S.
[J]. JOURNAL OF WILDLIFE DISEASES, 2015, 51 (01) : 113 - 124
[6] Marburgvirus Resurgence in Kitaka Mine Bat Population after Extermination Attempts, Uganda
Amman, Brian R.
Nyakarahuka, Luke
McElroy, Anita K.
Dodd, Kimberly A.
Sealy, Tara K.
Schuh, Amy J.
Shoemaker, Trevor R.
Balinandi, Stephen
Atimnedi, Patrick
Kaboyo, Winyi
Nichol, Stuart T.
Towner, Jonathan S.
[J]. EMERGING INFECTIOUS DISEASES, 2014, 20 (10) : 1761 - 1764
[7] Seasonal Pulses of Marburg Virus Circulation in Juvenile Rousettus aegyptiacus Bats Coincide with Periods of Increased Risk of Human Infection
Amman, Brian R.
Carroll, Serena A.
Reed, Zachary D.
Sealy, Tara K.
Balinandi, Stephen
Swanepoel, Robert
Kemp, Alan
Erickson, Bobbie Rae
Comer, James A.
Campbell, Shelley
Cannon, Deborah L.
Khristova, Marina L.
Atimnedi, Patrick
Paddock, Christopher D.
Crockett, Rebekah J. Kent
Flietstra, Timothy D.
Warfield, Kelly L.
Unfer, Robert
Katongole-Mbidde, Edward
Downing, Robert
Tappero, Jordan W.
Zaki, Sherif R.
Rollin, Pierre E.
Ksiazek, Thomas G.
Nichol, Stuart T.
Towner, Jonathan S.
[J]. PLOS PATHOGENS, 2012, 8 (10):
[8] Marburg hemorrhagic fever associated with multiple genetic lineages of virus
Bausch, Daniel G.
Nichol, Stuart T.
Muyembe-Tamfum, Jean Jacques
Borchert, Matthias
Rollin, Pierre E.
Sleurs, Hilde
Campbell, Patricia
Tshioko, Florimund K.
Roth, Catherine
Colebunders, Robert
Pirard, Patricia
Mardel, Simon
Olinda, Loku A.
Zeller, Herve
Tshomba, Antoine
Kulidri, Amayo
Libande, Modeste L.
Mulangu, Sabue
Formenty, Pierre
Grein, Thomas
Leirs, Herwig
Braack, Leo
Ksiazek, Tom
Zaki, Sherif
Bowen, Michael D.
Smit, Sheilagh B.
Leman, Patricia A.
Burt, Felicity J.
Kemp, Alan
Swanepoel, Robert
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (09) : 909 - 919
[9] West Africa 2013 Ebola: From Virus Outbreak to Humanitarian Crisis
Bausch, Daniel G.
[J]. MARBURG- AND EBOLAVIRUSES: FROM ECOSYSTEMS TO MOLECULES, 2017, 411 : 63 - 92
[10] Virulence of Marburg Virus Angola Compared to Mt. Elgon (Musoke) in Macaques: A Pooled Survival Analysis
Blair, Paul W.
Keshtkar-Jahromi, Maryam
Psoter, Kevin J.
Reisler, Ronald B.
Warren, Travis K.
Johnston, Sara C.
Goff, Arthur J.
Downey, Lydia G.
Bavari, Sina
Cardile, Anthony P.
[J]. VIRUSES-BASEL, 2018, 10 (11):

← 1 2 3 4 5 6 →