Noncoding RNAs in gastric cancer: Research progress and prospects

被引:85
作者
Zhang, Meng [1 ,2 ]
Du, Xiang [1 ,2 ]
机构
[1] Fudan Univ, Shanghai Canc Ctr, Dept Pathol, 270 Dongan Rd, Shanghai 200032, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, Dept Pathol, Shanghai 200032, Peoples R China
基金
中国国家自然科学基金;
关键词
Noncoding RNAs; Gastric cancer; MicroRNA; Long ncRNAs; PIWI-interacting RNAs; Competing endogenous RNA; COMPETING ENDOGENOUS RNA; PROMOTES CELL-PROLIFERATION; POOR-PROGNOSIS; CIRCULAR RNA; UP-REGULATION; MESENCHYMAL TRANSITION; TUMOR-SUPPRESSOR; LONG; HOTAIR; EXPRESSION;
D O I
10.3748/wjg.v22.i29.6610
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Noncoding RNAs (ncRNAs) have attracted much attention in cancer research field. They are involved in cellular development, proliferation, differentiation and apoptosis. The dysregulation of ncRNAs has been reported in tumor initiation, progression, invasion and metastasis in various cancers, including gastric cancer (GC). In the past few years, an accumulating body of evidence has deepened our understanding of ncRNAs, and several emerging ncRNAs have been identified, such as PIWI-interacting RNAs (piRNAs) and circular RNAs (circRNAs). The competing endogenous RNA (ceRNA) networks include mRNAs, microRNAs, long ncRNAs (lncRNAs) and circRNAs, which play critical roles in the tumorigenesis of GC. This review summarizes the recent hotspots of ncRNAs involved in GC pathobiology and their potential applications in GC. Finally, we briefly discuss the advances in the ceRNA network in GC.
引用
收藏
页码:6610 / 6618
页数:9
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