Resorcylic Acid Lactones from an Ilyonectria sp.

被引：20

作者：

Zhou, Jia ^{[1
]}

Gao, Ying ^{[1
]}

Chang, Jin-Ling ^{[1
]}

Yu, Heng-Yi ^{[2
]}

Chen, Juan ^{[1
]}

Zhou, Ming ^{[1
]}

Meng, Xiang-Gao ^{[3
]}

Ruan, Han-Li ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Hosp Affiliated, Dept Pharm, Wuhan 430030, Peoples R China

[3] Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2020年 / 83卷 / 05期

基金：

中国国家自然科学基金;

关键词：

BIOSYNTHESIS; ANALOGS;

D O I：

10.1021/acs.jnatprod.9b01167

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Twelve new resorcylic acid lactones (RALs) including three new 16-membered RALs (1a, 1b and 2), eight new 14-membered RALs (3-10), and one new 12-membered RAL (11), along with five known 14-membered RALs (12-16), were identified from the fermentation of the soil-derived fungus Ilyonectria sp. sb65. Their structures were established by detailed analyses of 1D and 2D NMR, HRESIMS, and X-ray diffraction crystallography. All new compounds were evaluated for their cytotoxic effects against three human cancer cell lines, along with their potential as TRAIL sensitizers in TRAIL-resistant A549 human lung adenocarcinoma cells and their in vitro immunosuppressive effects against ConA-induced T-cell and LPS-induced B-cell proliferation.

引用

页码：1505 / 1514

页数：10

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