Sexual dysfunction in women with epilepsy

被引：44

作者：

Harden, Cynthia L. ^{[1
]}

机构：

[1] Weill Cornell Med Coll, Comprehens Epilepsy Ctr, Dept Neurol, New York, NY 10021 USA

来源：

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY | 2008年 / 17卷 / 02期

关键词：

sexual dysfunction; epilepsy; women; antiepileptic drugs; anorgasmia; temporal lobe epilepsy; serotonin;

D O I：

10.1016/j.seizure.2007.11.010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Sexual dysfunction in women with epilepsy (WWE) is an important comorbidity. A significant minority of WWE have markedly decreased sexual interest and it appears that orgasmic dysfunction occurs more frequently in WWE than in control women. Enzyme-inducing antiepileptic drugs can adversely affect sexual functioning by decreasing bioactive testosterone levels. Temporal lobe epilepsy of right-sided versus left-sided origin may also be a risk factor for sexual dysfunction. In addition to these factors, emerging evidence suggests that the serotonin transporter protein is related to temporal lobe epilepsy and it is postulated that this transporter may play a rote in altered sexual functioning in epilepsy, perhaps through the serotonergic effects of antiepileptic drugs (AEDs). Strategies for modifying the contributors to sexual dysfunction in WWE will be discussed as well as the role of the neurologist in initiating management of this challenging comorbidity. (C) 2007 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

引用

页码：131 / 135

页数：5

共 24 条

[1] Sexual outcome after epilepsy surgery [J].

Baird, AD ;

Wilson, SJ ;

Bladin, PF ;

Saling, MM ;

Reutens, DC .

EPILEPSY & BEHAVIOR, 2003, 4 (03) :268-278

[2] Current issues in the management of epilepsy: The impact of frequent seizures on cost of illness, quality of life, and mortality [J].

Baker, GA ;

Nashef, L ;

vanHout, BA .

EPILEPSIA, 1997, 38 :S1-S8

[3] Report of the international consensus development conference on female sexual dysfunction: Definitions and classifications [J].

Basson, R ;

Berman, J ;

Burnett, A ;

Derogatis, L ;

Ferguson, D ;

Fourcroy, J ;

Goldstein, I ;

Graziottin, A ;

Heiman, J ;

Laan, E ;

Leiblum, S ;

Padma-Nathan, H ;

Rosen, R ;

Segraves, K ;

Segraves, RT ;

Shabsigh, R ;

Sipski, M ;

Wagner, G ;

Whipple, B .

JOURNAL OF UROLOGY, 2000, 163 (03) :888-893

[4] REDUCTION OF SEXUAL ACTIVITIES IN FEMALES TAKING ANTIEPILEPTIC DRUGS [J].

BERGEN, D ;

DAUGHERTY, S ;

ECKENFELS, E .

PSYCHOPATHOLOGY, 1992, 25 (01) :1-4

[5] REGIONAL EFFECTS OF SODIUM VALPROATE ON EXTRACELLULAR CONCENTRATIONS OF 5-HYDROXYTRYPTAMINE, DOPAMINE, AND THEIR METABOLITES IN THE RAT-BRAIN - AN INVIVO MICRODIALYSIS STUDY [J].

BIGGS, CS ;

PEARCE, BR ;

FOWLER, LJ ;

WHITTON, PS .

JOURNAL OF NEUROCHEMISTRY, 1992, 59 (05) :1702-1708

[6] Quantitative in vivo microdialysis study on the influence of multidrug transporters on the blood-brain barrier passage of oxcarbazepine: Concomitant use of hippocampal monoamines as pharmacodynamic markers for the anticonvulsant activity [J].

Clinckers, R ;

Smolders, I ;

Meurs, A ;

Ebinger, G ;

Michotte, Y .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2005, 314 (02) :725-731

[7] Anticonvulsant doses of carbamazepine increase hippocampal extracellular serotonin in genetically epilepsy-prone rats: Dose response relationships [J].

Dailey, JW ;

Reith, MEA ;

Yan, QS ;

Li, MY ;

Jobe, PC .

NEUROSCIENCE LETTERS, 1997, 227 (01) :13-16

[8] Sexual behavior and hemispheric laterality of the focus in patients with temporal lobe epilepsy [J].

Daniele, A ;

Azzoni, A ;

Bizzi, A ;

Rossi, A ;

Gainotti, G ;

Mazza, S .

BIOLOGICAL PSYCHIATRY, 1997, 42 (07) :617-624

[9] Sexual function in women with epilepsy [J].

Duncan, S ;

Blacklaw, J ;

Beastall, GH ;

Brodie, MJ .

EPILEPSIA, 1997, 38 (10) :1074-1081

[10]

Gerendai I, 2001, NEWS PHYSIOL SCI, V16, P92

← 1 2 3 →