Polymer-bound N-hydroxysuccinimide as a solid-supported additive for DCC-mediated peptide synthesis

被引：29

作者：

Chinchilla, R ^{[1
]}

Dodsworth, DJ ^{[1
]}

Nájera, C ^{[1
]}

Soriano, JM ^{[1
]}

机构：

[1] Univ Alicante, Dept Quim Organ, E-03080 Alicante, Spain

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 27期

关键词：

amino acids; coupling reagents; polymers; peptides;

D O I：

10.1016/S0040-4039(01)00763-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polymer-supported N-hydroxysuccinimide (P-HOSu) has been prepared from a styrene/maleic anhydride co-polymer and used as an easily removable activating and racemization-reducing additive for the peptide coupling of amino acid derivatives using DCC. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：4487 / 4489

页数：3

共 25 条

[1] Resin-supported labeling reagents [J].

Adamczyk, M ;

Fishpaugh, JR ;

Mattingly, PG .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (02) :217-220

[2] Preparation and use of N-hydroxysuccinimidyl active ester resins [J].

Adamczyk, M ;

Fishpaugh, JR ;

Mattingly, PG .

TETRAHEDRON LETTERS, 1999, 40 (03) :463-466

[3]

Albeiicio F., 2001, ORG PREP P INT, V33, P203, DOI DOI 10.1080/00304940109356592

[4]

Albericio F, 1997, METHOD ENZYMOL, V289, P104

[5]

Albericio F, 1997, METHOD ENZYMOL, V289, P313

[6]

Albericio F, 2000, SOLID-PHASE SYNTHESIS, P275

[7]

ANDREEV SM, 1977, SYNTHESIS-STUTTGART, P303

[8]

Bodansky M., 1979, PEPTIDES, V1, P105

[9]

Bodanszky M., 1993, PRINCIPLES PEPTIDE S, V2nd

[10] HOBT immobilized on macroporous polystyrene beads: a useful reagent for the synthesis of amides [J].

Dendrinos, K ;

Jeong, J ;

Huang, W ;

Kalivretenos, AG .

CHEMICAL COMMUNICATIONS, 1998, (04) :499-500

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