Oestrogen receptors and microsatellite instability in colorectal carcinoma patients

被引：22
作者：
Notarnicola, M
Gristina, R
Messa, C
Cariola, F
Fiorente, P
Caruso, ML
Gentile, M
Di Leo, A
机构：
[1] IRCCS Sci Inst Digest Dis S de Bellis, Biochem Lab, I-70013 Castellana Grotte, BA, Italy
[2] IRCCS Sci Inst Digest Dis S de Bellis, Med Genet Lab, I-70013 Castellana Grotte, BA, Italy
[3] IRCCS Sci Inst Digest Dis S de Bellis, Dept Pathol, I-70013 Castellana Grotte, BA, Italy
来源：
CANCER LETTERS | 2001年 / 168卷 / 01期
关键词：
oestrogen receptor; microsatellite instability; colorectal cancer;
D O I：
10.1016/S0304-3835(01)00494-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
About 10-15% of sporadic colorectal cancers show microsatellite instability (MIN), a mutator phenotype of mismatch repair genes. It seems that oestrogens may inhibit the pathway to colorectal carcinoma which involves a mismatch repair deficiency. Oestrogen receptorial status was evaluated in the neoplastic tissue and uninvolved surrounding mucosa of 17 MIN-positive and 33 MIN-negative tumours using an immunoenzymatic assay. MIN status was examined using the polymerase chain reaction and specific microsatellite markers. MIN was significantly associated with very low levels of oestrogen receptor in tumour tissue. Our findings suggest that MIN-positive tumours might lose a possible oestrogenic modulation mechanism. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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收藏
页码：65 / 70
页数：6
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