Long-term outcome after sequential resections of liver and lung metastases from colorectal carcinoma

被引:27
作者
Marudanayagam, Ravi [1 ]
Ramkumar, Krishnamoorthy [1 ]
Shanmugam, Vivekanandan [1 ]
Langman, Gerald [3 ]
Rajesh, Pala [2 ]
Coldham, Chris [1 ]
Bramhall, Simon R. [1 ]
Mayer, David [1 ]
Buckels, John [1 ]
Mirza, Darius F. [1 ]
机构
[1] Univ Hosp Birmingham NHS Trust, Queen Elizabeth Hosp, Liver Unit, Birmingham B15 2TH, W Midlands, England
[2] Heart England Fdn NHS Trust, Birmingham Heartlands Hosp, Dept Thorac Surg, Birmingham, W Midlands, England
[3] Heart England Fdn NHS Trust, Birmingham Heartlands Hosp, Dept Pathol, Birmingham, W Midlands, England
关键词
Sequential resections; liver and lung metastasectomy;
D O I
10.1111/j.1477-2574.2009.00115.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: Surgical resection of colorectal liver metastases (CLM) is an established form of treatment. Limited data exists on the value of sequential hepatic and pulmonary metastasectomy. We analysed patients who underwent sequential liver and lung resections for CLM. Methods: A total of 910 patients who underwent liver resection for CLM between January 2000 and December 2007, were analysed to identify patients with resectable pulmonary metastases (n = 43; 4.7%). Patient demographics, overall survival and survival difference between synchronous and metachronous pulmonary metastasectomy groups were compared. In addition, outcomes in the 'liver and lung resection' group were compared with a matched group of 'liver resection only' patients (matched for age, primary disease stage, interval to liver resection and liver disease stage). Results: Forty-three patients (median age 62, range 43-83 years, 22 males) underwent sequential liver and lung resection. A total of 36 patients underwent major hepatic resections, 18 patients had bilobar disease and the median number of liver lesions resected was 3 (range 1-5 lesions). Ten patients had synchronous liver and lung metastases. The median interval between liver and lung metastasectomy was 25 months (range 2-88 months). A total of two patients underwent major lobectomies, three patients had bilateral disease and the median number of lung lesions resected was one (range 1-3). The 1-, 3- and 5-year overall survival rates after first metastasectomy were 100%, 87.1% and 53.9%, respectively, with a median survival of 42 months. Patients: Undergoing metachronous pulmonary metastasectomy had better 1-, 3- and 5-year survival rates than those with synchronous disease (100%, 88.9% and 60.9% vs. 100%, 75% and 0%, respectively; P = 0.02, log rank test). There was no significant survival difference between the 'liver and lung resection' and the 'liver resection only' groups. Conclusion: Sequential liver and lung resection for CLM is associated with good long-term survival in selected patients, except in those presenting with synchronous lung and liver metastases.
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收藏
页码:671 / 676
页数:6
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