Molecularly imprinted polymers in the drug discovery process

被引：44
作者：
Rathbone, DL [1 ]
机构：
[1] Aston Univ, Sch Life & Hlth Sci, Birmingham B4 7ET, W Midlands, England
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2005年 / 57卷 / 12期
关键词：
combinatorial chemistry; molecular imprinting; receptor mimics; cross-reactivity; multiple templates; composite template;
D O I：
10.1016/j.addr.2005.07.017
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Since molecularly imprinted polymers (MIPs) are designed to have a memory for their molecular templates it is easy to draw parallels with the affinity between biological receptors and their substrates. Could MIPS take the place of natural receptors in the selection of potential drug molecules from synthetic compound libraries? To answer that question this review discusses the results of MIP Studies which attempt to emulate natural receptors. In addition the possible use Of MIPS to guide a compound library synthesis towards a desired biological activity is highlighted. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：1854 / 1874
页数：21
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